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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Calcitonin Gene Related Peptide (CGRP) Antibody/311-CGRP/100 µl
产品编号:311-CGRP
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Calcitonin Gene Related Peptide (CGRP) Antibody/311-CGRP/100 µl
商品介绍

Mousemonoclonalantibody

Size:
100µl
Formulation:
ProteinGPurified
Specificity:
Rat,Human,Mostmammals
Applications:
ICC1:50-1:100
Species:
Mouse
GeneName:
CALCA
CiteThisAntibody:
PhosphoSolutionsCat#311-CGRP,RRID:AB_2492054
Antigen/Purification:ExpandCollapse

Theantigenisaratalpha-CGRP.

TheantibodyisproteinGpurified.

BIOLOGicalSignificance:ExpandCollapse

CalcitoninGeneRelatedPeptide[CGRP]isa37aminoacidpeptideandisthemostpotentendogenousvasodilatorcurrentlyknown(Brainetal.,1985).CGRPisprimarilyproducedinnervoustissue,however,itsreceptorsareexpressedthroughoutthebody.CGRPisalsostronglyimplicatedinthevasodilatoryeffectofendogenouscannABInoidanandamideinthebrain.Thiseffectwasfoundtobeantagonizedbycapsazepine.CGRPisalsocurrentlyamajortargetofresearchinregardstofactorseffectingtheonsetofmigraineheadaches(EdvinssonL.,2003).CGRPantibodieshavebeenusedsuccessfullyinimmunoneutralization(Wongetal.,1993)

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternblots.

Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1yearafterdateofreceipt.Avoidfreeze/thawcycles.

GeneralReferences

BrainSD,WilliamsTJ,TippinsJR,MorrisHR,MacIntyreI(1985)Calcitoningenerelatedpeptideisapotentvasodilator.Nature313(5997):54-6

EdvinssonL(2003)Newtherapeutictargetinprimaryheadaches—blockingtheCGRPreceptor.ExpertOpinTherTargets.7(3):377-83

WongHC,Tache’Y,LloudKCK,YangH,SterniniC,HolzerP,WalshJH(1993)Monoclonalantibodytoratalpha-CGRP:production,characterization,andinvivoimmunoneutralizationactivity.Hybridoma.12:93-106.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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