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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/GABAB R2 (Ser783) Antibody/p1148-783/100 µl
产品编号:p1148-783
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/GABAB R2 (Ser783) Antibody/p1148-783/100 µl
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Rat,Mouse,Human,Xenopus,Bovine,Chicken,Non-humanprimate
Applications:
WB1:1,000IF1:500
Species:
Rabbit
GeneName:
GABBR2
MolecularReference:
~102kDa
CiteThisAntibody:
PhosphoSolutionsCat#p1148-783,RRID:AB_2492117
Antigen/Purification:ExpandCollapse

Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser783ofGABAB.

Theantibodyispreparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

Gamma-aminobutyricacid(GABA)istheprimaryinhibitoryneurotransmitterinthecentralnervoussystem.TherearetwomajorclassesofGABAreceptors:theGABAAandtheGABABsubtypeofreceptors.GABABreceptorsareheterodimericGprotein-coupledreceptorsthatmediateslowsynapticinhibitioninthecentralnervoussystem.IthasrecentlybeendemonstratedthatAMPKbindsdirectlytoGABABreceptorsandphosphorylatesS783inthecytoplasmictailoftheR2subunitandthatS783playsacriticalroleinenhancingneuronalsurvivalafterischemiaasphosphorylationofS783isevidentinmanybrainregionsandisincreaseddramaticallyafterischemicinjurytothebrain(Kuramotoetal.,2007).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

ProductSpecificReferences

Kim,S.H.,Park,S.,Yu,H.S.,Ko,K.H.,Park,H.G.andKim,Y.S.,2017.TheantipsychoticagentclozapineinducesautophagyviatheAMPK-ULK1-Beclin1signalingpathwayintheratfrontalcortex.ProgressinNeuro-PsychopharmacologyandBiologicalPsychiatry.PMID:29079139

deVelasco,E.M.F.,Hearing,M.,Xia,Z.,Victoria,N.C.,Luján,R.,&Wickman,K.(2015).SexdifferencesinGABABR-GIRKsignalinginlayer5/6pyramidalneuronsofthemouseprelimbiccortex.Neuropharmacology.Aug;95:353-60.PMID:25843643

TerunumaM,HaydonPG,PangalosMN,MossSJ.(2015).PurinergicreceptoractivationfacilitatesastrocyticGABABreceptorcalciumsignalling.Neuropharmacology88:74-81.PMID:25261019

TerunumaM,Revilla-SanchezR,QuadrosIM,DengQ,DeebTZ,LumbM,SicinskiP,HaydonPG,PangalosMN,MossSJ.(2014).PostsynapticGABABreceptoractivityregulatesexcitatoryneuronalarchitectureandspatialmemory.JNeurosci.34:804-816.PMID:24431439

TerunumaM,VargasKJ,WilkinsME,RamírezOA,Jaureguiberry-BravoM,PangalosMN,SmartTG,MossSJ,CouveA.(2010).ProlongedactivationofNMDAreceptorspromotesdephosphorylationandalterspostendocyticsortingofGABABreceptors.ProcNatlAcadSciUSA107:13918-13923.PMID:20643948

KuramotoN,WilkinsME,FairfaxBP,Revilla-SanchezR,TerunumaM,TamakiK,IemataM,WarrenN,CouveA,CalverA,HorvathZ,FreemanK,CarlingD,HuangL,GonzalesC,CooperE,SmartTG,PangalosMN,MossSJ(2007)Phospho-dependentfunctionalmodulationofGABA(B)receptorsbythemetabolicsensorAMP-dependentproteinkinase.Neuron53:233-247.PMID:17224405

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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