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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Testicular Receptor 2 (TR2) Antibody/2002-TR2/100 µl
产品编号:2002-TR2
市  场 价:¥3911.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$295.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Testicular Receptor 2 (TR2) Antibody/2002-TR2/100 µl
商品介绍

Rabbitpolyclonalantibody

Size:
100µl
Formulation:
Neatserum
Specificity:
Rat,Mouse,Human
Applications:
WB1:1,000
Species:
Rabbit
MolecularReference:
~64kDa
CiteThisAntibody:
PhosphoSolutionsCat#2002-TR2,RRID:AB_2492264
Antigen/Purification:ExpandCollapse

TheantigenisafusionproteinfromN-terminalpeptideofmouseTR2.

Theantibodyisneatserum.

BIOLOGicalSignificance:ExpandCollapse

Testicularreceptor2(TR2)isamemberoftheorphannuclearreceptorfamily.Itiswidelyexpressedatalowlevelthroughouttheadulttestis.TR2repressestranscriptionandbindsDNAdirectlyinteractingwithHDAC3andHDAC4viaDNA-bindingdomains(Francoetal.,2003).TR2hasalsobeenimplicatedinregulationofestrogenreceptoractivityinmammaryglands(Hunetal.,2002).Inaddition,TR2hasrecentlybeenshowntoformaheterodimerwithTR4thatcanbindtothedirectrepeat6elementofthehepatitisBvirus(HBV)enhancerIIregionthussuppressingHBVgeneexpression(Linetal.,2008).

Storage

Neatserum.

Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.

GeneralReferences

FrancoPJ,LiG,WeiLN(2003)InteractionofnuclearreceptorzincfingerDNAbindingdomainswithhistonedeacetylase.MolCellEndocrinol.206(1-2):1-12.

HuYC,ShyrCR,CheW,MuXM,KimE,ChangC.(2002)Suppressionofestrogenreceptor-mediatedtranscriptionandcellgrowthbyinteractionwithTR2orphanreceptor.JBiolChem.2002277(37):33571-9.

LinTJ,YangRY,LeeHJ.(2008)CollectiverepressionofthehepatitisBvirusenhancerIIbyhumanTR4andTR2orphanreceptors.HepatolRes.38(1):79-84.

TanabeO,McPheeD,KobayashiS,ShenY,BrandtW,JiangX,CampbellAD,ChenYT,ChangC,YamamotoM,TanimotoK,EngelJD.“Embryonicandfetalbeta-globingenerepressionbytheorphannuclearreceptors,TR2andTR4.”EMBOJ.2007,26:2295-306.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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