Rabbitpolyclonalantibody
TheantigenisafusionproteinfromN-terminalpeptideofmouseTR2.
Theantibodyisneatserum.
Testicularreceptor2(TR2)isamemberoftheorphannuclearreceptorfamily.Itiswidelyexpressedatalowlevelthroughouttheadulttestis.TR2repressestranscriptionandbindsDNAdirectlyinteractingwithHDAC3andHDAC4viaDNA-bindingdomains(Francoetal.,2003).TR2hasalsobeenimplicatedinregulationofestrogenreceptoractivityinmammaryglands(Hunetal.,2002).Inaddition,TR2hasrecentlybeenshowntoformaheterodimerwithTR4thatcanbindtothedirectrepeat6elementofthehepatitisBvirus(HBV)enhancerIIregionthussuppressingHBVgeneexpression(Linetal.,2008).
Neatserum.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
FrancoPJ,LiG,WeiLN(2003)InteractionofnuclearreceptorzincfingerDNAbindingdomainswithhistonedeacetylase.MolCellEndocrinol.206(1-2):1-12.
HuYC,ShyrCR,CheW,MuXM,KimE,ChangC.(2002)Suppressionofestrogenreceptor-mediatedtranscriptionandcellgrowthbyinteractionwithTR2orphanreceptor.JBiolChem.2002277(37):33571-9.
LinTJ,YangRY,LeeHJ.(2008)CollectiverepressionofthehepatitisBvirusenhancerIIbyhumanTR4andTR2orphanreceptors.HepatolRes.38(1):79-84.
TanabeO,McPheeD,KobayashiS,ShenY,BrandtW,JiangX,CampbellAD,ChenYT,ChangC,YamamotoM,TanimotoK,EngelJD.“Embryonicandfetalbeta-globingenerepressionbytheorphannuclearreceptors,TR2andTR4.”EMBOJ.2007,26:2295-306.
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