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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Connexin43 (Ser368) Antibody/p1007-368/100 µl
产品编号:p1007-368
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Connexin43 (Ser368) Antibody/p1007-368/100 µl
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Rat,Mouse,Human,Bovine,Chicken,Zebrafish,Canine,GuineaPig
Applications:
WB1:1,000
Species:
Rabbit
MolecularReference:
~43kDa
CiteThisAntibody:
PhosphoSolutionsCat#p1007-368,RRID:AB_2492064
Antigen/Purification:ExpandCollapse

Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser368ofratconnexin43.

Theantibodyispreparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

Gapjunctionalintercellularcommunicationisthoughttoplayakeyroleindevelopmentandmayalsobeinvolvedinepilepsy(Aronicaetal.,2001).Connexin43formsgap-junctionalchannelsandregulatesthepermeABIlityofthesegapjunctionstosmallorganicmolecules.Permeabilityofconnexin43isknowntoberegulatedbyphosphorylationatSer368byproteinkinaseC(Yogoetal.,2002;Baoetal.,2004a).PhosphorylationofSer368 byPKCinducesaconformationalchangeofconnexin43thatresultsinadecreaseingapjunctionpermeability(Baoetal.,2004b).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgBSApermland50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

AronicaE,GorterJA,JansenGH,LeenstraS,YankayaB,TroostD(2001)Expressionofconnexin43andconnexin32gap-junctionproteinsinepilepsy-associatedbraintumorsandintheperilesionalepilepticcortex.ActaNeuropathol(Berl)101:449-459.

BaoX,AltenbergGA,ReussL(2004a)Mechanismofregulationofthegapjunctionproteinconnexin43byproteinkinaseC-mediatedphosphorylation.AmJPhysiolCellPhysiol286:C647-C654.

BaoX,ReussL,AltenbergGA(2004b)Regulationofpurifiedandreconstitutedconnexin43hemichannelsbyproteinkinaseC-mediatedphosphorylationofSerine368.JBiolChem279:20058-20066.

YogoK,OgawaT,AkiyamaM,IshidaN,TakeyaT(2002)IdentificationandfunctionalanalysisofnovelphosphorylationsitesinCx43inratprimarygranulosacells.FEBSLett531:132-136.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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