请使用支持JavaScript的浏览器!
主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/FTO Antibody/597-FTO/100 µl
产品编号:597-FTO
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/FTO Antibody/597-FTO/100 µl
商品介绍

Mousemonoclonalantibody

Size:
100µl
Formulation:
ProteinGPurified
Specificity:
Rat,Mouse,Human
Applications:
WB1:1,000IF1:100
Species:
Mouse
MolecularReference:
~58kDa
CiteThisAntibody:
PhosphoSolutionsCat#597-FTO,RRID:AB_2492098
Antigen/Purification:ExpandCollapse

TheantigenissyntheticpeptidefromtheN-terminalregionofratFTO.

TheantibodyisProteinGpurifiedculturesupernatant.

BIOLOGicalSignificance:ExpandCollapse

TheFTOgeneisthemostrobustgeneforcommonobesitycharacterizedtodate.FTOgeneexpressionhasbeenfoundtobesignificantlyupregulatedinthehypothalamusofratsafterfooddeprivationandstronglynegativelycorrelatedwiththeexpressionoforexinpeptidewhichisinvolvedinthestimulationoffoodintake(FredrickssonRetal.,2008).DeletionanalysisofFTOgeneinmiceshowedthatFtoisfunctionallyinvolvedinthecontrolofbothenergyintakeandenergyexpenditure(FischerJetal.,2009).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgBSApermland50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforuptooneyearafterdateofreceipt.Avoidfreeze/thawcycles.

ProductSpecificReferences

Guan,B.J.,vanHoef,V.,Jobava,R.,Elroy-Stein,O.,Valasek,L.S.,Cargnello,M.,Gao,X.H.,Krokowski,D.,Merrick,W.C.,Kimball,S.R.andKomar,A.A.,2017.AUniqueISRProgramDeterminesCellularResponsestoChronicStress.MolecularCell,68(5),pp.885-900.PMID:29220654

Yu,J.,Chen,M.,Huang,H.,Zhu,J.,Song,H.,Zhu,J.,Park,J.andJi,S.J.,2017.Dynamicm6AmodificationregulateslocaltranslationofmRNAinaxons.NucleicAcidsResearch.Nov23.PMID:29186567

Zhou,J.,Wan,J.,Gao,X.,Zhang,X.,Jaffrey,S.R.,&Qian,S.B.(2015).Dynamicm6AmRNAmethylationdirectstranslationalcontrolofheatshockresponse.Nature,526(7574),591-594.PMID:26458103

Gulati,P.,Avezov,E.,Ma,M.,Antrobus,R.,Lehner,P.,O’Rahilly,S.,&Yeo,G.S.(2014).Fatmassandobesity-related(FTO)shuttlesbetweenthenucleusandcytoplasm.Biosciencereports,34(5),621-628.PMID:25242086

GulatiP,CheungMK,AntrobusR,ChurchCD,HardingHP,TungYC,RimmingtonD,MaM,RonD,LehnerPJ,AshcroftFM,CoxRD,CollAP,O’RahillyS,YeoGS(2013)Rolefortheobesity-relatedFTOgeneinthecellularsensingofaminoacids.ProcNatlAcadSciUSA.Jan28.PMID:23359686

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

自营商城图标
厂家直采
全球直采 正品优价
正品保障图标
正品保障
厂家直发 有线跟踪
解放采购图标
正规清关
CIF100%正规报关,提供发票
及时交付图标
及时交付
限时必达 不达必赔