Rabbitpolyclonalantibody
Theantigenisa peptidefromfasciclindomain1ofmouseperiostin.
Theantibodyisaffinitypurified.
Periostinisamatricellularprotein,i.e.anextracellularmatrixproteinthatinteractsbothwithotherECMproteinsandwithcell-surfacereceptors.Likemanyothermatricellularproteins,thefunctionofperiostinisimportantbothinembryonicdevelopmentandintheremodelingofadulttissuesinresponsetopathologicalinsults.Periostinwasoriginallyisolatedasanosteoblast-specificMarkerthatfunctionsasacelladhesionmoleculeforpreosteoblastsandisthoughttobeinvolvedinosteoblastrecruitment,attachmentandspreADIng(Kruzynska-FrejtagA.etal.,2004).Periostinhasrecentlybeenshowntopromotecollagenfibrogenesis,inhibitdifferentiationofProgenitorcellsintocardiomyocytesandtobeessentialinmaintainingthebiomechanicalpropertiesoftheadultmyocardium(Norrisetal.,2008)
LiquidinPBS.Containsnopreservative.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
Kruzynska-FrejtagA,WangJ,RogersR,KrugE,HoffmanS,MarkwaldRR,ConwaySJ.(2004)Periostinisexpressedwithinthedevelopingteethatthesitesofepithelial-mesenchymalinteraction.DevelopDynamics,229:857-868.
NorrisRA,BorqTK,ButcherJT,BaudinoTA,BanerjeeI,MarkwaldRR(2008)Neonatalandadultcardiovascularpathophysiologicalremodelingandrepair:developmentalroleofperiostin.AnnNYAcadSci.1123:30-40.
NorrisRA,DamonB,MironovV,KasyanovV,RamamurthiA,Moreno-RodriguezR,TruskT,PottsJD,GoodwinRL,DavisJ,HoffmanS,WenX,SugiY,KernCB,MjAATvedtCH,TurnerDK,OkaT,ConwaySJ,MolkentinJD,ForgacsG,MarkwaldRR.(2007)Periostinregulatescollagenfibrillogenesisandthebiomechanicalpropertiesofconnectivetissues.JCellBiochem.101(3):695-711.
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