Rabbitpolyclonalantibody
- Size:
- 100µl
- Formulation:
- Affinitypurified
- Specificity:
- Rat,Mouse,Human,Chicken
- Applications:
- WB1:1,000IHC1:100
- Species:
- Rabbit
- MolecularReference:
- ~93kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#1621-PERI,RRID:AB_2492205
Antigen/Purification:Collapse
Theantigenisabacterialfusionproteinequivalenttoa188-aminoacidpolypeptidefromtheC-Terminalregionofmouseperiostinwhichiscomprisedofsixsmallalternatively-splicedexons.
Theantibodyisaffinitypurified.
BIOLOGicalSignificance:Collapse
Periostinisamatricellularprotein,i.e.anextracellularmatrixproteinthatinteractsbothwithotherECMproteinsandwithcell-surfacereceptors.Likemanyothermatricellularproteins,thefunctionofperiostinisimportantbothinembryonicdevelopmentandintheremodelingofadulttissuesinresponsetopathologicalinsults.Periostinwasoriginallyisolatedasanosteoblast-specificMarkerthatfunctionsasacelladhesionmoleculeforpreosteoblastsandisthoughttobeinvolvedinosteoblastrecruitment,attachmentandspreADIng(Kruzynska-FrejtagA.etal.,2004).Periostinhassincebeendemonstratedtobeimportantinheartvalvedevelopmentandmyocardialinfarctionbecauseitpromotescollagenfibrogenesis,inhibitsdifferentiationofProgenitorcellsintocardiomyocytesandisessentialinmaintainingthebiomechanicalpropertiesoftheadultmyocardium(Norrisetal.,2008).
Storage
LiquidinPBS.Containsnopreservative.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
ProductSpecificReferences
Bains,SN,TourkinaE,AtkinsonC,JosephK,TholanikunnelB,ChuHW,RiemerEC,MartinR,HoffmanS(2012)Lossofcaveolin-1frombronchialepithelialcellsandmonocytesinhumansubjectswithasthma.Allergy.2012Dec;67(12):1601-4.PMID:23004679
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik，他们在 Paul Greengard 博士的实验室共同工作，Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区，是一支敬业、友好、勤奋的科学家团队，致力于为您提供最优质的抗体和业内客户支持。
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