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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Alpha Synuclein (Ser129) Antibody/p1571-129/100 µl
产品编号:p1571-129
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Alpha Synuclein (Ser129) Antibody/p1571-129/100 µl
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Rat,Mouse,Human,Bovine,Non-humanprimate,Canine
Applications:
WB1:1000
Species:
Rabbit
GeneName:
SNCA
MolecularReference:
~15kDa
CiteThisAntibody:
PhosphoSolutionsCat#p1571-129,RRID:AB_2492038
Antigen/Purification:ExpandCollapse

Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser129ofalphasynuclein.

Theantibodyispreparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

Alpha-synucleinisapresynapticneuronalproteinthatisthoughttobeinvolvedintheformationofSNAREcomplexes.Mostsignificantly,aggregatedalphasynucleinisoneofthemajorcomponentsfoundintheLewybodiesthatoccurinParkinson’sdisease(PD)andotherneurodegenerativedisorders(Okochietal.,2000).Mutationofthealpha-synucleingeneisassociatedwithfamilialformsofPD(Newmannetal.,2002).Recentevidencesuggeststhatphosphorylationofalpha-synucleinatSer129playsaroleintheformationofinclusionsinPD(Smithetal.,2005;Masliahetal.,2005).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

OkochiM,WalterJ,KoyamaA,NakajoS,BabaM,IwatsuboT,MeijerL,KahlePJ,HaassC(2000)ConstitutivephosphorylationoftheParkinson’sdiseaseassociatedalphasynuclein.JBiolChemJan7;275(1):390-7.

NeumannM,KahlePJ,GiassonBI,OzmenL,BorroniE,SpoorenW,MullerV,OdoyS,FujiwaraH,HasegawaM,IwatsuboT,TrojanowskiJQ,KretzschmarHA,HaassC(2002)Misfoldedproteinasekresistanthyperphosphorylatedalpha-synucleininagedtransgenicmicewithlocomotordeteriorationandinhumanalphasynucleinopathies.JClinInvestNov;110(10):1403-5.

SmithWW,MargolisRL,LiX,TroncosoJC,LeeMK,DawsonVL,DawsonTM,IwatsuboT,RossCA(2005)Alpha-synucleinphosphorylationenhanceseosinophiliccytoplasmicinclusionformationinSH-SY5YCells.JNeurosciJune8;25(23):5544-5552.

MasliahE,RockensteinE,AdameA,AlfordM,CrewsL,HashimotoM,SuebertP,LeeM,GoldsteinJ,ChilcoteT,GamesD,SchenkD(2005)Effectsofalpha-synucleinimmunizationinamousemodelofParkinson’sdisease.NeuronJun16;46(6):857-868.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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