Mousemonoclonalantibody
TheantigenisafulllengthhumanalphasynucleinexpressedinE.Coli.
TheantibodyisProteinGpurified.
Alpha-synucleinisapresynapticneuronalproteinthatisthoughttobeinvolvedintheformationofSNAREcomplexes.Mostsignificantly,aggregatedalpha-synucleinisoneofthemajorcomponentsfoundintheLewybodiesthatoccurinParkinson’sdisease(PD)andotherneurodegenerativedisorders(Okochietal.,2000).EarlyonsetParkinson’sdiseasemaybecausedbyaduplicationortriplicationofoneofthealphasynucleingenes(ChartierHarlinMCetal.,2004andSingleton,ABetal.,2005).Alpha-synucleinisalsofoundintheLewybodiesofpatientswithdiffuseLewybodydiseaseandinclusionsinglialcellsinthebrainsofpatientswithmultiplesystematrophy(MSA)andamyotrophiclateralsclerosis(ALS).
100µlliquidcontaining10mMsodiumazide.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
OkochiM,WalterJ,KoyamaA,NakajoS,BabaM,IwatsuboT,MeijerL,KahlePJ,HaassC(2000)ConstitutivephosphorylationoftheParkinson’sdiseaseassociatedalpha-synuclein.JBiolChemJan7;275(1):390-7.
Chartier-Harlin,MC.etal.Alpha-synucleinlocusduplicationasacauseoffamilialParkinson’sdisease.Lancet364:1167-1169(2004).
Singleton,ABetal.Alpha-synucleinlocustriplicationcausesParkinson’sdisease.Science302:841(2003).
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。