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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/c-FOS Antibody/309-cFOS/100 µl
产品编号:309-cFOS
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/c-FOS Antibody/309-cFOS/100 µl
商品介绍

Mousemonoclonalantibody

Size:
100µl
Formulation:
ProteinGpurified
Specificity:
Bovine,Human,Mouse,Rat
Applications:
WB1:2000IF1:1000IHC1:1000
Species:
Mouse
MolecularReference:
~50kDa
CiteThisAntibody:
PhosphoSolutionsCat#309-cFOS,RRID:AB_2632380
Antigen/Purification:ExpandCollapse

Theantigenisrecombinantfulllengthhumanc-FOSexpressedinandpurifiedfromE.Coli.

TheantibodyisproteinGpurifiedfromculturesupernatant.

BIOLOGicalSignificance:ExpandCollapse

c-FOSisamemberoftheFOStranscriptionfactorfamilywhichformsdimerswithc-JUNtoproducetheActivatorProtein1(AP-1)complexwhichplaysakeyroleincriticalcellularprocessessuchascellproliferation,differentiationandapoptosis(Chiuetal.,1988). c-FOSexpressionhasbeendemonstratedtobeausefulMarkerofneuronalactivationasitisrapidlyinducedfollowingvariousstimuli(Hoffmanetal.,1993). Additionally,c-FOShasbeenshowntobeoverexpressedinavarietyofmalignanttumortypes(Milde-Langosch2005).

Storage

100µlinPBS+5mMsodiumazide.

Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.

GeneralReferences

Chiu,R.,Boyle,W.J.,Meek,J.,Smeal,T.,Hunter,T.,&Karin,M.(1988).Thec-fosproteininteractswithc-junAP-1tostimulatetranscriptionofAP-1responsivegenes.Cell,54(4),541-552.

Hoffman,G.E.,Smith,M.S.,&Verbalis,J.G.(1993).c-Fosandrelatedimmediateearlygeneproductsasmarkersofactivityinneuroendocrinesystems.Frontiersinneuroendocrinology,14(3),173-213.

Milde-Langosch,K.(2005).TheFosfamilyoftranscriptionfactorsandtheirroleintumourigenesis.Europeanjournalofcancer,41(16),2449-2461.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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