Mousemonoclonalantibody
Theantigenisrecombinantfulllengthhumanc-FOSexpressedinandpurifiedfromE.Coli.
TheantibodyisproteinGpurifiedfromculturesupernatant.
c-FOSisamemberoftheFOStranscriptionfactorfamilywhichformsdimerswithc-JUNtoproducetheActivatorProtein1(AP-1)complexwhichplaysakeyroleincriticalcellularprocessessuchascellproliferation,differentiationandapoptosis(Chiuetal.,1988). c-FOSexpressionhasbeendemonstratedtobeausefulMarkerofneuronalactivationasitisrapidlyinducedfollowingvariousstimuli(Hoffmanetal.,1993). Additionally,c-FOShasbeenshowntobeoverexpressedinavarietyofmalignanttumortypes(Milde-Langosch2005).
100µlinPBS+5mMsodiumazide.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
Chiu,R.,Boyle,W.J.,Meek,J.,Smeal,T.,Hunter,T.,&Karin,M.(1988).Thec-fosproteininteractswithc-junAP-1tostimulatetranscriptionofAP-1responsivegenes.Cell,54(4),541-552.
Hoffman,G.E.,Smith,M.S.,&Verbalis,J.G.(1993).c-Fosandrelatedimmediateearlygeneproductsasmarkersofactivityinneuroendocrinesystems.Frontiersinneuroendocrinology,14(3),173-213.
Milde-Langosch,K.(2005).TheFosfamilyoftranscriptionfactorsandtheirroleintumourigenesis.Europeanjournalofcancer,41(16),2449-2461.
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。