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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/ATRIP (Ser239) Antibody/p116-239/100 µl
产品编号:p116-239
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/ATRIP (Ser239) Antibody/p116-239/100 µl
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Mouse,Human,Bovine,Non-humanprimate,Sheep
Applications:
WB1:500
Species:
Rabbit
MolecularReference:
~86kDa
CiteThisAntibody:
PhosphoSolutionsCat#p116-239,RRID:AB_2492046
Antigen/Purification:ExpandCollapse

Theantigenisa  phosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser239ofhumanATRIP.

Theantibodyispreparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

ATRIP,ATRinteractingprotein,bindstoATRtoregulateATRexpression,andisanessentialcomponentoftheDNAdamagecheckpointpathway(Cortezetal,2001).ATRisrecruitedtoDNAlesionsinpartthroughitsassociationwithATRIP,whichinturninteractswiththesingle-strandedDNAbindingproteinRPA(Balletal,2007).DNAreplicationforksmaystallasaresultofDNAdamagecausingphosphorylationofseveralproteins,includingBRCA1whencolocalizingwithATR/ATRIPcomplexandRPA(Venereetal,2007).TheDNAreplicationforkstallcoincideswithBRCA1directlyphosphorylatingATRIPatSer239(Venereetal,2007).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

CortezD,GuntukuS,QinJ,ElledgeSJ(2001)ATRandATRIP:partnersincheckpointsignaling.Science294(5547):1713-6.

BallHL,EhrhardtMR,MordesDA,GlickGG,ChazinWJ,CortexD.(2007)FunctionofaconservedcheckpointrecruitmentdomaininATRIPproteins.MolCelBiol.27(9):3367-77.

VenereM,SynderA,Zgheib,andHalazonetisT.(2007)PhosphorylationofATR-intereactingProtienonSer239MediatesanInteractionwithBreast-OvarianCancerSusceptibility1andCheckpointFunction.CancerRes67(13):6100-5

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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