Rabbitpolyclonalantibody
TheantigenisasyntheticpeptidefromtheC-terminalregionofhumancollagenIα1telopeptidesequence.
Theantibodyisaffinitypurified.
Collagenisanextracellularmatrixproteinthatservesasascaffolddefiningtheshapeandmechanicalpropertiesofmanytissuesandorgansincludingskin,tendon,arterywalls,fibrocartilage,boneandteeth.Type1collagenisthemostabundantproteininmammals.CollagensaresynthesizedwithN-terminalandC-terminalpropeptidesthatarecleavedduringmaturationandsecretion.Aftercleavageofthepropeptides,themostN-terminalandC-terminalremainingsequencesareknownastelopeptides.Mutationsinthecollagen1,alpha1gene(COL1A1)areknowntocauseosteogenesisimperfecta(akabrittlebonedisease)(Byers1989).FurThermore,mutationsfoundinthefirst90residuesofthehelicalregionofalpha1collagenhavebeenimplicatedinthepreventionordelayedremovaloftheprocollagenN-propeptideleADIngtoacombinedosteogenesisimperfectaandEhlers-Danlossyndrome(EDS)phenotype(Cabraletal.,2005).
LiquidinPBS.Containsnopreservative.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cuptosixmonthsafterdateofreceipt.Avoidfreeze/thawcycles.
ReeseC,LeeR,BonnerM,PerryB,HeywoodJ,SilverRM,TourkinaE,ViscontiRP,HoffmanS.(2014)Fibrocytesinthefibroticlung:alteredphenotypedetectedbyflowcytometry.FrontPharmacol.2014Jun16;5:141.PMID:24999331
Bains,SN,TourkinaE,AtkinsonC,JosephK,TholanikunnelB,ChuHW,RiemerEC,MartinR,HoffmanS(2012)Lossofcaveolin-1frombronchialepithelialcellsandmonocytesinhumansubjectswithasthma.Allergy.2012Dec;67(12):1601-4. PMID:23004679
WesselsA,vandenHoffMJ,AdamoRF,PhelpsAL,LockhartMM,SaulsK,BriggsLE,NorrisRA,vanWijkB,Perez-PomaresJM,DettmanRW,BurchJB.(2012)Epicardiallyderivedfibroblastspreferentiallycontributetotheparietalleafletsoftheatrioventricularvalvesinthemurineheart.DevBiol.2012Jun15;366(2):111-24.PMID:22546693
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。