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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Collagen I, alpha 1, telopeptide Antibody/322-COLT/100 µl
产品编号:322-COLT
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Collagen I, alpha 1, telopeptide Antibody/322-COLT/100 µl
商品介绍

Rabbitpolyclonalantibody

Size:
100µl
Formulation:
Affinitypurified
Specificity:
Rat,Mouse,Human,Sheep
Applications:
WB1:1,000IHC1:100
Species:
Rabbit
MolecularReference:
~140kDa
CiteThisAntibody:
PhosphoSolutionsCat#322-COLT,RRID:AB_2492061
Antigen/Purification:ExpandCollapse

TheantigenisasyntheticpeptidefromtheC-terminalregionofhumancollagenIα1telopeptidesequence.

Theantibodyisaffinitypurified.

BIOLOGicalSignificance:ExpandCollapse

Collagenisanextracellularmatrixproteinthatservesasascaffolddefiningtheshapeandmechanicalpropertiesofmanytissuesandorgansincludingskin,tendon,arterywalls,fibrocartilage,boneandteeth.Type1collagenisthemostabundantproteininmammals.CollagensaresynthesizedwithN-terminalandC-terminalpropeptidesthatarecleavedduringmaturationandsecretion.Aftercleavageofthepropeptides,themostN-terminalandC-terminalremainingsequencesareknownastelopeptides.Mutationsinthecollagen1,alpha1gene(COL1A1)areknowntocauseosteogenesisimperfecta(akabrittlebonedisease)(Byers1989).FurThermore,mutationsfoundinthefirst90residuesofthehelicalregionofalpha1collagenhavebeenimplicatedinthepreventionordelayedremovaloftheprocollagenN-propeptideleADIngtoacombinedosteogenesisimperfectaandEhlers-Danlossyndrome(EDS)phenotype(Cabraletal.,2005).

Storage

LiquidinPBS.Containsnopreservative.

Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cuptosixmonthsafterdateofreceipt.Avoidfreeze/thawcycles.

ProductSpecificReferences

ReeseC,LeeR,BonnerM,PerryB,HeywoodJ,SilverRM,TourkinaE,ViscontiRP,HoffmanS.(2014)Fibrocytesinthefibroticlung:alteredphenotypedetectedbyflowcytometry.FrontPharmacol.2014Jun16;5:141.PMID:24999331

Bains,SN,TourkinaE,AtkinsonC,JosephK,TholanikunnelB,ChuHW,RiemerEC,MartinR,HoffmanS(2012)Lossofcaveolin-1frombronchialepithelialcellsandmonocytesinhumansubjectswithasthma.Allergy.2012Dec;67(12):1601-4. PMID:23004679

WesselsA,vandenHoffMJ,AdamoRF,PhelpsAL,LockhartMM,SaulsK,BriggsLE,NorrisRA,vanWijkB,Perez-PomaresJM,DettmanRW,BurchJB.(2012)Epicardiallyderivedfibroblastspreferentiallycontributetotheparietalleafletsoftheatrioventricularvalvesinthemurineheart.DevBiol.2012Jun15;366(2):111-24.PMID:22546693

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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