Rabbitpolyclonalantibody
- Size:
- 100µl
- Formulation:
- Affinitypurified
- Specificity:
- Rat,Mouse
- Applications:
- WB1:1,000IHC1:100-1:200
- Species:
- Rabbit
- GeneName:
- SLC6A1
- MolecularReference:
- ~67kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#880-GAT1,RRID:AB_2492119
Antigen/Purification:Collapse
TheantigenisapeptidecorrespondingtoaminoacidresiduesfromtheC-terminalregionofratGAT-1.
Theantibodyispreparedfromrabbitserumbyaffinitypurificationviachromatographywithacolumnmadewiththepeptideusedasantigen.
BIOLOGicalSignificance:Collapse
Gamma-aminobutyricacid(GABA)istheprimaryinhibitoryneurotransmitterinthecentralnervoussystem,causingahyperpolarizationofthemembranethroughtheopeningofaCl−channelassociatedwiththeGABAAreceptor(GABAA-R)subtype.GABAplasmamembranetransporters(GATs)influencesynapticneurotransmissionbyhighaffinityuptakeandreleaseofGABA.Todate,fourdistinctGABAtransportershavebeenidentified:GAT-1,GAT-2,GAT-3,andBGT-1.GAT-1,themostabundantofthetransporters,isfoundpredominantlyinneurons,butalsoinsomespecializedglia(Minellietal.,1995).GAT-1isthoughttoplayakeyroleinepileptogenesis(Zhaoetal.2003).
Storage
100µlin10mMHEPES(pH7.5),150mMNaCl,100µgBSApermland50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.
Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.
ProductSpecificReference
Johnson,J.,Chen,T.K.,Rickman,D.W.,Evans,C.,&Brecha,N.C.(1996).Multipleγ-aminobutyricacidplasmamembranetransporters(GAT-1,GAT-2,GAT-3)intheratretina.TheJournalofcomparativeneurology,375(2),212.PMID:8915826
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik，他们在 Paul Greengard 博士的实验室共同工作，Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区，是一支敬业、友好、勤奋的科学家团队，致力于为您提供最优质的抗体和业内客户支持。
本网站将在规定时间内给予删除等相关处理。
