Rabbitpolyclonalantibody

Size:

150µl

Formulation:

AffinityPurifiedfromPooledSerum

Specificity:

Rat,Mouse,Human,Non-humanprimate

Applications:

WB1:1,000IHC1:1,000

Species:

Rabbit

GeneName:

GRIA1

MolecularReference:

~100kDa

CiteThisAntibody:

PhosphoSolutionsCat#p1160-845,RRID:AB_2492128

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgBSApermland50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

ProductSpecificReferences

Tronci,E.,Napolitano,F.,Muñoz,A.,Fidalgo,C.,Rossi,F.,Björklund,A.,Usiello,A.andCarta,M.,2017.BDNFover-expressioninducesstriatalSEROtoninfibersproutingandincreasesthesusceptibilitytol-DOPA-induceddyskinesiain6-OHDA-lesionedrats.ExperimentalNeurology.PMID:28757258

Lameth,J.,Gervais,A.,Colin,C.,Lévêque,P.,Jay,T.M.,Edeline,J.M.andMallat,M.,2017.AcuteNeuroinflammationPromotesCellResponsesto1800MHzGSMElectromagneticFieldsintheRatCerebralCortex.NeurotoxicityResearch,pp.1-16.PMID:28578480

Andrade,E.C.,Musante,V.,Horiuchi,A.,Matsuzaki,H.,Brody,A.H.,Wu,T.,Greengard,P.,Taylor,J.R.andNairn,A.C.,2017.ARPP-16isastriatal-enrichedinhibitorofproteinphosphatase2Aregulatedbymicrotubule-associatedserine/threoninekinase3(Mast3kinase).JournalofNeuroscience,pp.4559-15.PMID:28167675

O’Leary,H.,Bernard,P.B.,Castano,A.M.,&Benke,T.A.(2016).EnhancedlongtermpotentiationanddecreasedAMPAreceptordesensitizationintheacuteperiodfollowingasinglekainateinducedearlylifeseizure.Neurobiologyofdisease,87,134-144. PMID:26706598

Xue,B.,Chen,E.C.,He,N.,Jin,D.Z.,Mao,L.M.,&Wang,J.Q.(2016).IntegratedregulationofAMPAglutamatereceptorphosphorylationinthestriatumbydopamineandacetylcholine.Neuropharmacology.PMID:27060412

Xue,B.,Fitzgerald,C.A.,Jin,D.Z.,Mao,L.M.,&Wang,J.Q.(2016).Amphetamineelevatesphosphorylationofeukaryoticinitiationfactor2α(eIF2α)intheratforebrainviaactivatingdopamineD1andD2receptors.BrainResearch.PMID:27338925

Ip,F.C.,Fu,W.Y.,Cheng,E.Y.,Tong,E.P.,Lok,K.C.,Liang,Y.,Ye,W.C.&Ip,N.Y.(2015).AnemosideA3EnhancesCognitionthroughtheRegulationofSynapticFunctionandNeuroprotection.Neuropsychopharmacology,40,1877–1887. PMID:25649278

Mao,L.M.,Xue,B.,Jin,D.Z.,&Wang,J.Q.(2015).DynamicincreasesinAMPAreceptorphosphorylationintherathippocampusinresponsetoamphetamine.Journalofneurochemistry.Jun;133(6):795-805.SuzukiK,HaradaA,ShiraishiE,KimuraH.(2015)InVivoPharmacologicalCharacterizationofTAK-063,aPotentandSelectivePhosphodiesterase10AInhibitorwithAntipsychotic-LikeActivityinRodents.JPET,352:471-479. PMID:25689263

Tassin,T.C.,Benavides,D.R.,Plattner,F.,Nishi,A.,&Bibb,J.A.(2015).RegulationofERKKinasebyMEK1KinaseInhibitionintheBrain.JournalofBiologicalChemistry,Jun26;290(26):16319-29. PMID:25971971

Mao,L.M.,Hastings,J.M.,Fibuch,E.E.,&Wang,J.Q.(2014).PropofolselectivelyaltersGluA1AMPAreceptorphosphorylationinthehippocampusbutnotprefrontalcortexinyoungandagedmice.Europeanjournalofpharmacology,738,237-244. PMID:24907515

Meyer,D.A.,Torres-Altoro,M.I.,Tan,Z.,Tozzi,A.,DiFilippo,M.,DiNapoli,V.,Plattner,F.,Kansy,J.W.,Benkovic,S.A.,Huber,J.D.,Miller,D.B.,Greengard,P.,Calabresi,P.,Rosen,C.L.,&Bibb,J.A.(2014).IschemicstrokeinjuryismediatedbyaberrantCdk5.TheJournalofNeuroscience,34(24),8259-8267. PMID:24920629

Wang,J.,Zhang,Y.,Xu,H.,Zhu,S.,Wang,H.,He,J.,Zhang,H.,Guo,H.,Kong,J.,Huang,Q.,&Li,X.M.(2014).FluoxetineImprovesBehavioralPerformancebySuppressingtheProductionofSolubleβ-AmyloidinAPP/PS1Mice.CurrentAlzheimerResearch,11(7),672-680.PMID: 25115542

Xue,B.,Edwards,M.C.,Mao,L.M.,Guo,M.L.,Jin,D.Z.,Fibuch,E.E.,&Wang,J.Q.(2014).RapidandsustainedGluA1S845phosphorylationinsynapticandextrasynapticlocationsintheratforebrainfollowingamphetamineadmiNISTration.Neurochemistryinternational,64,48-54. PMID:24231469

Bernard,P.B.,Castano,A.M.,Bayer,K.U.,&Benke,T.A.(2014).Necessary,butnotsufficient:insightsintothemechanismsofmGluRmediatedlong-termdepressionfromaratmodelofearlylifeseizures.Neuropharmacology,84,1-12. PMID:24780380

ShenY,FuWY,ChengEY,FuAK,andIpNY(2013)Melanocortin-4receptorregulateshippocampalsynapticplasticitythroughaproteinkinaseA-dependentmechanism.JNeurosci.33(2):464-72. PMID:23303927

SantiniE,FeyderM,GangarossaG,BateupHS,GreengardP,FisoneG.(2012)Dopamine-andcAMP-regulatedphosphoproteinof32-kDa(DARPP-32)-dependentactivationofextracellularsignal-regulatedkinase(ERK)andmammaliantargetofrapamycincomplex1(mTORC1)signalinginexperimentalparkinsonism.JBiolChem.287(33):27806-12. PMID:22753408

RobertM.Sears,Rong-JianLiu,NandakumarS.Narayanan,RuthSharf,MarkF.Yeckel,MarkLaubach,GeorgeK.Aghajanian,andRalphJ.DiLeone(2010)RegulationofNucleusAccumbensActivitybytheHypothalamicNeuropeptideMelanin-ConcentratingHormone.J.Neurosci.,30:8263–8273. PMID:20554878

EmanuelaSantini,MyriamHeiman,PaulGreengard,EmmanuelValjent,andGilbertoFisone(2009)InhibitionofmTORSignalinginParkinson’sDiseasePreventsL-DOPA–InducedDyskinesia.Sci.Signal.,Jul2009;2:ra36. PMID:19622833

HeikeRebholz,AkinoriNishi,SABIneLiebscher,AngusC.Nairn,MarcFlajolet,andPaulGreengard(2009)CK2negativelyregulatesGssignaling.PNAS,106:14096–14101.PMID:19666609

ZhaoqingZhengandJoyceKeifer(2009)PKAHasaCriticalRoleinSynapticDeliveryofGluR1-andGluR4-ContainingAMPARsDuringInitialStagesofAcquisitionofInVitroClassicalConditioning.JNeurophysiol,101:2539–2549. PMID:19261706

KurtisD.Davies,SusanM.Goebel-Goody,StevenJ.Coultrap,andMichaelD.Browning(2008)LongTermSynapticDepressionThatIsAssociatedwithGluR1DephosphorylationbutNot-Amino-3-hydroxy-5-methyl-4-isoxazolepropionicAcid(AMPA)ReceptorInternalization.J.Biol.Chem.,283:33138–33146. PMID:18819923

DouglasA.Meyer,EdmondRicher,StanleyA.Benkovic,KanehiroHayashi,JaniceW.Kansy,CarlyF.Hale,LilyY.Moy,YongKim,JamesP.O’Callaghan,Li-HueiTsai,PaulGreengard,AngusC.Nairn,ChristopherW.Cowan,DianeB.Miller,PietroAntich,andJamesA.Bibb(2008)StriataldysregulationofCdk5alterslocomotorresponsestococaine,motorlearning,anddendriticmorphology.PNAS,105:18561–18566. PMID:19017804

AkinoriNishi,MahomiKuroiwa,DianeB.Miller,JamesP.O’Callaghan,HelenS.Bateup,TakahideShuto,NaokiSotogaku,TakaichiFukuda,NathanielHeintz,PaulGreengard,andGretchenL.Snyder(2008)DistinctRolesofPDE4andPDE10AintheRegulationofcAMP/PKASignalingintheStriatum.J.Neurosci.,28:10460–10471.PMID:18923023

SunX,MilovanovicM,ZhaoY,WolfME.(2008)AcuteandchronicdopaminereceptorstimulationmodulatesAMPAreceptortraffickinginnucleusaccumbensneuronscoculturedwithprefrontalcortexneurons.JNeurosci.Apr16;28(16):4216-30.PMID:18417701

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik，他们在 Paul Greengard 博士的实验室共同工作，Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区，是一支敬业、友好、勤奋的科学家团队，致力于为您提供最优质的抗体和业内客户支持。