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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/GluR2 (Ser880) Antibody/p1170-880/100 µl
产品编号:p1170-880
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/GluR2 (Ser880) Antibody/p1170-880/100 µl
商品介绍

Rabbitpolyclonalantibody

Size:
100µl
Formulation:
Affinitypurified
Specificity:
Rat,Mouse,Human,Chicken,Non-humanprimate,Zebrafish
Applications:
WB1:1000
Species:
Rabbit
GeneName:
GRIA2
MolecularReference:
~100kDa
CiteThisAntibody:
PhosphoSolutionsCat#p1170-880,RRID:AB_2492131
Antigen/Purification:ExpandCollapse

TheantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephosphoSer880ofratGluR2.

Theantibodyispreparedfromrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

 

BIOLOGicalSignificance:ExpandCollapse

Theionchannelsactivatedbyglutamatearetypicallydividedintotwoclasses.ThosethataresensitivetoN-methyl-D-aspartate(NMDA)aredesignatedNMDAreceptors(NMDAR)whilethoseactivatedbyα-amino-3-hydroxy-5-methyl-4-isoxalonepropionicacid(AMPA)areknownasAMPAreceptors(AMPAR).TheAMPARarecomprisedoffourdistinctglutamatereceptorsubunitsdesignated(GluR1-4)andtheyplaykeyrolesinvirtuallyallexcitatoryneurotransmissioninthebrain(Keinänenetal.,1990;HollmannandHeinemann,1994).ThenumberofGluR2subunitsintheAMPAreceptorcomplexaffectstheCa2+permeABIlity,rectificationandsingle-channelconductanceofAMPAreceptors.Ser880hasbeenidentifiedasthePKCphosphorylationsitewithintheC-terminalregionofGluR2andhasbeenshowntodifferentiallyregulatetheinteractionofthePDZdomain-containingproteinsGRIP1andPICK1(Matsudaetal.,1999)

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended. Storeat–20°C;stableforatleastoneyear.

ProductSpecificReferences

Lameth,J.,Gervais,A.,Colin,C.,Lévêque,P.,Jay,T.M.,Edeline,J.M.andMallat,M.,2017.AcuteNeuroinflammationPromotesCellResponsesto1800MHzGSMElectromagneticFieldsintheRatCerebralCortex.NeurotoxicityResearch,pp.1-16.PMID:28578480

Singer,B.F.,Bubula,N.,Przybycien-Szymanska,M.M.,Li,D.andVezina,P.,2016.Stimuliassociatedwiththepresenceorabsenceofamphetamineregulatecytoskeletalsignalingandbehavior.EuropeanNeuropsychopharmacology.PMID:27720500

O’Leary,H.,Bernard,P.B.,Castano,A.M.,&Benke,T.A.(2016).EnhancedlongtermpotentiationanddecreasedAMPAreceptordesensitizationintheacuteperiodfollowingasinglekainateinducedearlylifeseizure.Neurobiologyofdisease,87,134-144.PMID:26706598

Xue,B.,Edwards,M.C.,Mao,L.M.,Guo,M.L.,Jin,D.Z.,Fibuch,E.E.,&Wang,J.Q.(2014).RapidandsustainedGluA1S845phosphorylationinsynapticandextrasynapticlocationsintheratforebrainfollowingamphetamineadmiNISTration.NeuRochemistryinternational,64,48-54.PMID:24231469

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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