Rabbitpolyclonalantibody
PooledSerum- Size:
- 100µl
- Formulation:
- AffinityPurifiedfromPooledSerum
- Specificity:
- Rat,Mouse,Human,Chicken,Non-humanprimate,Zebrafish
- Applications:
- WB1:1,000
- Species:
- Rabbit
- GeneName:
- GRIA2
- MolecularReference:
- ~100kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#900-GluR2,RRID:AB_2492129
Antigen/Purification:Collapse
Theantigenisa peptidecorrespondingtoaminoacidresiduesfromratGluR2,conjugatedtokeyholelimpethemocyanin(KLH).
Theantibodyispreparedfrompooledrabbitserumbyaffinitypurificationonacolumnmadewiththepeptideantigen.
BIOLOGicalSignificance:Collapse
Theionchannelsactivatedbyglutamatearetypicallydividedintotwoclasses.ThosethataresensitivetoN-methyl-D-aspartate(NMDA)aredesignatedNMDAreceptors(NMDAR)whilethoseactivatedbyα-amino-3-hydroxy-5-methyl-4-isoxalonepropionicacid(AMPA)areknownasAMPAreceptors(AMPAR).TheAMPARarecomprisedoffourdistinctglutamatereceptorsubunitsdesignated(GluR1-4)andtheyplaykeyrolesinvirtuallyallexcitatoryneurotransmissioninthebrain(Keinänenetal.,1990;HollmannandHeinemann,1994).TheGluR2subunitisthoughttoplayakeyroleinformsofsynapticplasticitysuchasLTD(Chungetal.,2003).
Storage
100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.
Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.
ProductSpecificReferences
Lameth,J.,Gervais,A.,Colin,C.,Lévêque,P.,Jay,T.M.,Edeline,J.M.andMallat,M.,2017.AcuteNeuroinflammationPromotesCellResponsesto1800MHzGSMElectromagneticFieldsintheRatCerebralCortex.NeurotoxicityResearch,pp.1-16.PMID:28578480
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik，他们在 Paul Greengard 博士的实验室共同工作，Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区，是一支敬业、友好、勤奋的科学家团队，致力于为您提供最优质的抗体和业内客户支持。
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