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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Amyloid Precursor Protein Antibody/144-APP/100 µl
产品编号:144-APP
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Amyloid Precursor Protein Antibody/144-APP/100 µl
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Rat,Mouse,Human,Non-humanprimate,Canine
Applications:
WB1:1000
Species:
Rabbit
MolecularReference:
~115kDa
CiteThisAntibody:
PhosphoSolutionsCat#144-APP,RRID:AB_2492039
Antigen/Purification:ExpandCollapse

TheantigenisapeptidecorrespondingtoaminoacidresiduesfromtheC-terminalregionofratAPP.

Theantibodyis preparedfrompooledrabbitserumbyaffinitypurificationonacolumnmadewiththeC-terminalpeptideusedasantigen.

 

BIOLOGicalSignificance:ExpandCollapse

Alargebodyofevidencehasimplicatedtheamyloidprecursorprotein(APP)inthepathogenesisofAlzheimer’sdisease(AD)(Kamenetzetal.,2003).ThephosphorylationofAPPatThr668isthoughttoplayacriticalroleingenerationofthesolubleAPP(beta)andbeta-amyloidpeptide(abeta)whicharethemajorcomponentsofsenileplaquesinpatientbrainsinflictedwithAD(Liuetal.,2003;Andoetal.,2001).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

AndoK,IijimaKI,ElliottJI,KirinoY,SuzukiT(2001)Phosphorylation-dependentregulationoftheinteractionofamyloidprecursorproteinwithFe65affectstheproductionofbeta-amyloid.JBiolChem276:40353-40361.
KamenetzF,TomitaT,HsiehH,SeabrookG,BorcheltD,IwatsuboT,SisodiaS,MalinowR(2003)APPprocessingandsynapticfunction.Neuron37:925-937.
LiuF,SuY,LiB,ZhouY,RyderJ,Gonzalez-DeWhittP,MayPC,NiB(2003)Regulationofamyloidprecursorprotein(APP)phosphorylationandprocessingbyp35/cdk5andp25/cdk5.FEBSLett547:193-196

 

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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