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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/EWS Antibody/540-EWS/100 µl
产品编号:540-EWS
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/EWS Antibody/540-EWS/100 µl
商品介绍

Mousemonoclonalantibody

Size:
100µl
Formulation:
ProteinGPurified
Specificity:
Human
Applications:
WB1:1000IHC1:500
Species:
Mouse
MolecularReference:
~85kDa
CiteThisAntibody:
PhosphoSolutionsCat#540-EWS,RRID:AB_2650521
Antigen/Purification:ExpandCollapse

TheantigenisrecombinantfulllengthhumanEWSexpressedinandpurifiedfromE.Coli.

TheantibodyisProteinGpurifiedfromculturesupernatant.

BIOLOGicalSignificance:ExpandCollapse

TheEwingSarcomaBreakpointRegion1(EWSR1)geneencodestheEWSprotein,whichalongwithFUSandTAF15comprisestheFETfamilyofRNA-bindingproteins. EWSisprimarilyexpressedinthenucleus,buthasalsobeenfoundinthecytoplasmofsecretorycelltypes(Anderssonetal.,2008). DefectsofEWSR1areknowntocauseEwingsarcomaandhavebeenimplicatedinamyotrophiclateralsclerosis(ALS)(Svetonietal.,2016). Recently,EWShasbeenshowntodirectlyinteractwithoncogenicETStranscriptionfactorsinthepromotionofprostatecancer(Kedageetal.,2016).

Storage

100µlinPBS+5mMsodiumazide.

Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.

GeneralReferences:

AnderssonMK,StåhlbergA,ArvidssonY,OlofssonA,SembH,StenmanG,NilssonO,AmanP(2008).ThemultifunctionalFUS,EWSandTAF15proto-oncoproteinsshowcelltype-specificexpressionpatternsandinvolvementincellspreADIngandstressresponse.BMCCellBiol.11:9:37.

SvetoniF,FrisoneP,ParonettoMP(2016)RoleofFETproteinsinneurodegenerativedisorders.RNABiol.2016Nov;13(11):1089-1102

KedageV,SelvarajN,NicholasTR,BudkaJA,PlotnikJP,JerdeTJ,HollenhorstPC(2016)AnInteractionwithEwing’sSarcomaBreakpointProteinEWSDefinesaSpecificOncogenicMechanismofETSFactorsRearrangedinProstateCancer.CellRep.2016Oct25;17(5):1289-1301.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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