Rabbitpolyclonalantibody
TheantigenisaSyntheticpeptidetakenfromtheCterminusofthe~32kDaactinfragment.
Theantibodyisneatserum.
Fractin(fragmentofactin)isacaspase-specificcleavageproductofactinandservesasanovelMarkerofapoptosis-relatedevents.Theantibodyhasbeenshowntodetecttheprocessesandcellbodiesofdegeneratingneuronsandplaque-associatedmicrogliainAlzheimer’sdisease(Yangetal.,1998).IthasrecentlybeenreportedthatFractinmayhaveafunctionalroleinapoptoticsignalinginoligodendrocytes(Schulz,R.,etal.,Glia,2009,inpress).
Liquid.Containsnopreservative.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforuptooneyearafterdateofreceipt.Avoidfreeze/thawcycles.
Yang,F,etal.,AntibodytoCaspase-CleavedActinDetectsApoptosisinDifferentiatedNeuroblastomaandPlaque-AssociatedNeuronsandMicrogliainAlzheimer’sdisease.AmericanJournalofPathology,1998,Vol.152,No.2,p.379-389.PMID:9466564
Rossiter,JP,etal.,Caspase-cleavedactin(fractin)immunolabelingofHiranobodies.NeuropatholApplNeurobiol.2000Aug;26(4):342-6. PMID:10931367
Asamec,E,etal.,Multiple-labelimmunocytochemistryfortheevaluationofnatureofcelldeathinexperimentalmodelsofneurodegeneration.BrainResProtoc.2001Jul;7(3):193-202.PMID:11431120
Chen,TA,etal.,Inhibitionofcaspase-3-likeactivityreducesglutamateinducedcelldeathinadultratretina.BrainRes.2001Jun15;904(1):177-88.PMID:11516428
Rossiter,JP,etal.,Caspase-3activationandcaspase-likeproteolyticactivityinhumanperinatalhypoxic-ischemicbraininjury.ActaNeuropathol.2002Jan;103(1):66-73.PMID:11841033
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