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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Fractin (fragment of actin) Antibody/592-FRAC/100 µl
产品编号:592-FRAC
市  场 价:¥3911.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$295.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Fractin (fragment of actin) Antibody/592-FRAC/100 µl
商品介绍

Rabbitpolyclonalantibody

Size:
100µl
Formulation:
Neatserum
Specificity:
Rat,Human
Applications:
WB1:1,000IHC1:100
Species:
Rabbit
MolecularReference:
~32kDa
CiteThisAntibody:
PhosphoSolutionsCat#592-FRAC,RRID:AB_2492097
Antigen/Purification:ExpandCollapse

TheantigenisaSyntheticpeptidetakenfromtheCterminusofthe~32kDaactinfragment.

Theantibodyisneatserum.

BIOLOGicalSignificance:ExpandCollapse

Fractin(fragmentofactin)isacaspase-specificcleavageproductofactinandservesasanovelMarkerofapoptosis-relatedevents.Theantibodyhasbeenshowntodetecttheprocessesandcellbodiesofdegeneratingneuronsandplaque-associatedmicrogliainAlzheimer’sdisease(Yangetal.,1998).IthasrecentlybeenreportedthatFractinmayhaveafunctionalroleinapoptoticsignalinginoligodendrocytes(Schulz,R.,etal.,Glia,2009,inpress).

Storage

Liquid.Containsnopreservative.

Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforuptooneyearafterdateofreceipt.Avoidfreeze/thawcycles.

ProductSpecificReferences

Yang,F,etal.,AntibodytoCaspase-CleavedActinDetectsApoptosisinDifferentiatedNeuroblastomaandPlaque-AssociatedNeuronsandMicrogliainAlzheimer’sdisease.AmericanJournalofPathology,1998,Vol.152,No.2,p.379-389.PMID:9466564

Rossiter,JP,etal.,Caspase-cleavedactin(fractin)immunolabelingofHiranobodies.NeuropatholApplNeurobiol.2000Aug;26(4):342-6. PMID:10931367

Asamec,E,etal.,Multiple-labelimmunocytochemistryfortheevaluationofnatureofcelldeathinexperimentalmodelsofneurodegeneration.BrainResProtoc.2001Jul;7(3):193-202.PMID:11431120

Chen,TA,etal.,Inhibitionofcaspase-3-likeactivityreducesglutamateinducedcelldeathinadultratretina.BrainRes.2001Jun15;904(1):177-88.PMID:11516428

Rossiter,JP,etal.,Caspase-3activationandcaspase-likeproteolyticactivityinhumanperinatalhypoxic-ischemicbraininjury.ActaNeuropathol.2002Jan;103(1):66-73.PMID:11841033

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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