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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/MeCP2 (Ser80) Antibody/p1205-80/100 µl
产品编号:p1205-80
市  场 价:¥3911.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$295.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/MeCP2 (Ser80) Antibody/p1205-80/100 µl
商品介绍

Rabbitpolyclonalantibody

Size:
100µl
Formulation:
Serum
Specificity:
Rat,Mouse,Human
Applications:
WB1:1,000IHC1:100
Species:
Rabbit
MolecularReference:
~75kDa
CiteThisAntibody:
PhosphoSolutionsCat#p1205-80,RRID:AB_2492144
Antigen/Purification:ExpandCollapse

Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser80ofMECP2(Methyl-CpGBindingProtein2)protein.

Theantibodyisserum.

BIOLOGicalSignificance:ExpandCollapse

MECP2(Methyl-CpGBindingProtein2)isachromosomalproteinthatbindstomethylatedDNA.Itcanbindspecificallytoasinglemethyl-CpGpairandisnotinfluencedbysequencesflankingthemethyl-CpGs.MECP2hasbeenshowntomediatetranscriptionalrepressionthroughinteractionwithhistonedeacetylaseandthecorepressorSIN3A.DefectsinMECP2arethecauseofRettsyndrome(RTT).RTTisanX-linkeddominantdisease,itisaprogressiveneurologicdevelopmentaldisorderandoneofthemostcommoncausesofmentalretardationinfemales.RecentstudieshavereportedanewphosphorylationsiteatSer80.PhosphorylationanddephosphorylationofthissitemaybeinvolvedinmodulatingthedynamicfunctionofMECP2inneuronstransitingbetweenrestingandactivestateswithinneuralcircuitsthatunderliebehaviors.(Taoetal.,2009)

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1yearafterdateofreceipt.Avoidfreeze/thawcycles.

ProductSpecificReferences

Maphis,N.M.,Jiang,S.,Binder,J.,Wright,C.,Gopalan,B.,Lamb,B.T.andBhaskar,K.,2017.WholeGenomeExpressionAnalysisinaMouseModelofTauopathyIdentifiesMECP2asaPossIBLeRegulatorofTauPathology.FrontiersinMolecularNeuroscience,10:69. PMID:28367114

TaoJ,HuK,ChangQ,WuH,ShermanNE,MartinowichK,KloseRJ,SchanenC,JaenischR,WangW,SunYE(2009)PhosphorylationofMeCP2atSerine80regulatesitschromatinassociationandneurologicalfunction.ProcNatlAcadSciUSA.106(12):4882-7. PMID:19225110

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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