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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Gap-43 (Ser41) Antibody/p1150-41/100 µl
产品编号:p1150-41
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Gap-43 (Ser41) Antibody/p1150-41/100 µl
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Rat,Mouse,Human,Xenopus,Bovine,Chicken,Non-humanprimate,Zebrafish,Canine
Applications:
WB1:1,000
Species:
Rabbit
MolecularReference:
~50kDa
CiteThisAntibody:
PhosphoSolutionsCat#p1150-41,RRID:AB_2492123
Antigen/Purification:ExpandCollapse

Theantigenisa phosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser41ofGap-43.

Theantibodyispreparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

Gap-43isthoughttohaveanimportantroleindevelopmentandplasticitybecauseitisexpressedathighlevelsinneuronalgrowthconesduringdevelopmentandduringaxonalregeneration(BenowitzandRouttenberg,1997).ThereisalsoevidencefromknockoutanimalsthatGap-43servestoamplifypathfindingsignalsfromthegrowthcone(Strittmatteretal.,1995).Gap-43isthoughttomediateatleastsomeoftheseeffectsviainteractionwithactin.Importantly,phosphorylationatSer41byproteinkinaseC(CatalogNo.1609-PKC)modulatestheinteractionofGap-43withactin(Heetal.,1997)andmayalsoaffectneurotransmitterreleaseduringformsofplasticitylikeLTP(Huloetal.,2002).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgBSApermland50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

ProductSpecificReferences

RayuduGopalakrishna,UshaGundimeda,JasonEricSchiffman,andThomasH.McNeill(2008)ADirectRedoxRegulationofProteinKinaseCIsoenzymesMediatesOxidant-inducedNeuritogenesisinPC12CellsJ.Biol.Chem.,May2008;283:14430–14444.PMID:18375950

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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