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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/GAP43 Antibody/875-GAP43/100 µl
产品编号:875-GAP43
市  场 价:¥3911.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$295.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/GAP43 Antibody/875-GAP43/100 µl
商品介绍

Chickenpolyclonalantibody

Size:
100µl
Formulation:
TotalIgYfraction
Specificity:
Rat,Mouse,Human
Applications:
WB1:2,000IF1:500
Species:
Chicken
MolecularReference:
~43kDa
CiteThisAntibody:
PhosphoSolutionsCat#875-GAP43,RRID:AB_2492122
Antigen/Purification:ExpandCollapse

TheantigenisasyntheticpeptidecorrespondingtoaminoacidresiduesfromtheC-terminalregionoftheratGAP43sequence.

TheantibodyistotalIgYfraction.

BIOLOGicalSignificance:ExpandCollapse

GAP-43isthoughttohaveanimportantroleindevelopmentandplasticitybecauseitisexpressedathighlevelsinneuronalgrowthconesduringdevelopmentandduringaxonalregeneration(BenowitzandRouttenberg,1997).ThereisalsoevidencefromknockoutanimalsthatGAP-43servestoamplifypathfindingsignalsfromthegrowthcone(Strittmatteretal.,1995).GAP-43isthoughttomediateatleastsomeoftheseeffectsviainteractionwithactin.Importantly,phosphorylationatSer41byproteinkinaseCmodulatestheinteractionofGAP-43withactin(Heetal.,1997)andmayalsoaffectneurotransmitterreleaseduringformsofplasticitylikeLTP(Huloetal.,2002).

Storage

TotalIgYfractioninPBS+10mMNaN3.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

BenowitzLI,RouttenbergA(1997)Gap-43:Anintrinsicdeterminantofneuronaldevelopmentandplasticit.TrendsNeurosci20:84-91.

He,Q,Dent,EW,Meiri,KF(1997)ModulationofactinfilamentbehaviorbyGap-43(neuromodulin)isdependentonthephosphorylationstatusofserine41,theproteinkinaseCsite.JNeurosci17:3515-3524.

HuloS,Alberi,S,LauxT,MullerD,CaroniP(2002)ApointmutantofGap-43inducesenhancedshort-termandlongtermhippocampalplasticity.EurJNeurosci15:1976-1982.

StrittmatterSM,FankhauserC,HuangPL,MashimoH,FishmanMC(1995)NeuronalpathfindingisabnormalinmicelackingtheneuronalgrowthconeproteinGap-43,”Cell80:445-452.

RayuduGopalakrishna,UshaGundimeda,JasonEricSchiffman,andThomasH.McNeill(2008)ADirectRedoxRegulationofProteinKinaseCIsoenzymesMediatesOxidant-inducedNeuritogenesisinPC12CellsJ.Biol.Chem.,May2008;283:14430–14444.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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