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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Calbindin Antibody/302-CALB/100 µl
产品编号:302-CALB
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Calbindin Antibody/302-CALB/100 µl
商品介绍

Mousemonoclonalantibody

Size:
100µl
Formulation:
ProteinGPurified
Specificity:
Rat,Mouse,Human,Bovine
Applications:
WB1:2,000IF1:1,000
Species:
Mouse
MolecularReference:
~28kDa
CiteThisAntibody:
PhosphoSolutionsCat#302-CALB,RRID:AB_2560939
Antigen/Purification:ExpandCollapse

TheantigenisarecombinantfulllengthhumancalbindinpurifiedfromE.coli.

Theantibodyis ProteinGpurified.

BIOLOGicalSignificance:ExpandCollapse

Calbindin(aka.calbindinD28k)isamemberofthecalcium-bindingproteinsuperfamilythatincludescalmodulinandtroponinC.Itispredominantlyexpressedincertaintypesofneurons,particularlyindendritesandperikaryaofthecerebellumandisthoughttobufferentryofcalciumuponstimulationofglutamatereceptors(Andressenetal.,1993). CalbindinhasrecentlybeenshowntoplayacriticalroleinmitochondrialdysfunctionandlossofsynapticproteinsinvivoinanAlzheimer’sdiseasemousemodel(Kooketal.,2014).

Storage

100µlininPBS+50%glyceroland5mMsodiumazide.

Forlongtermstorage–20°Cisrecommended.Storeat–20°Cinundilutedaliquots;stableforatleast1year.Avoidfreeze/thawcycles.

GeneralReferences

Andressen,C.,Blümcke,I.,&Celio,M.R.(1993).Calcium-bindingproteins:selectiveMarkersofnervecells.Cellandtissueresearch,271(2),181-208.

Kook,S.Y.,Jeong,H.,Kang,M.J.,Park,R.,Shin,H.J.,Han,S.H.,…&Mook-Jung,I.(2014).Crucialroleofcalbindin-D28kinthepathogenesisofAlzheimer’sdiseasemousemodel.CellDeath&Differentiation.21,1575–1587.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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