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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Choline Acetyltransferase Antibody, Goat/315-ChAT/100 µl
产品编号:315-ChAT
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Choline Acetyltransferase Antibody, Goat/315-ChAT/100 µl
商品介绍

Goatpolyclonalantibody

Size:
100µl
Formulation:
AffinityPurified
Specificity:
Rat,Mouse,Human,Chicken,Non-humanprimate,GuineaPig
Applications:
WB1:100IHC1:100
Species:
Goat
MolecularReference:
~70kDa
CiteThisAntibody:
PhosphoSolutionsCat#315-CHAT,RRID:AB_2492055
Antigen/Purification:ExpandCollapse

Theantigenisanativecholineacetyltransferasepurifiedfromhumanplacenta.

Theantibodyispreparedfromgoatserumbyaffinitypurificationusingacolumntowhichtheproteinimmunogenwascoupled.

BIOLOGicalSignificance:ExpandCollapse

CholineacetyltransferaseisaneuronalenzymewhichcatalyzesthereactionbetweenAcetylCoAandcholineresultingintheformationofacetylcholine.ItisthereforefoundprimarilyincholinergicneuronsmakingitavaluableMarkerfordiseasesassociatedwithdecreasedcholinergicfunctionsuchasSchizophrenia,Alzheimer’sdisease(AD)andDownsyndrome(Holtetal.1999).DecreasedcholineacetyltransferaseactivityinparticularhasbeenshowninSchizophrenicsubjects(Karsonetal1993).IthasfurThermorebeendemonstratedthatinpatientswithAD,therearesignificantlylowerlevelsofcorticalChATthatcorrelatewithseverityofthediseaseasmeasuredbylossofneuropsychologicalfunction(Baskinetal.1999).

Storage

100µlinPBS+5mg/mlBSA+0.2%NaN3.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

KarsonCN,CasanovaMF,KleinmanJE,GriffinWS(1993)Cholineacetyltransferaseinschizophrenia.Am.J.Psychiatry150:454-459.

HoltDJ,HermanMM,HydeTM,KleinmanJE,CintonCM,GermanDC,HershLB,GreybielAM,SaperCB(1999)Evidenceforadeficitincholinergicinterneuronsinthestriatuminschizophrenia.Neuroscience94(1):21-31.

BaskinDS,BrowningJL,PirozzoloFJ,KorporaalS,BaskinJA,AppelSH(1999)BraincholineacetyltransferaseandmentalfunctioninAlzheimerdisease.ArchNeurol.56:1121-1123.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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