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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Potassium Channel, Kv2.2 Subunit Antibody/1002-KV22/100 µl
产品编号:1002-KV22
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Potassium Channel, Kv2.2 Subunit Antibody/1002-KV22/100 µl
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Xenopus
Applications:
WB1:1,000IHC1:1,000
Species:
Rabbit
MolecularReference:
~125kDa
CiteThisAntibody:
PhosphoSolutionsCat#1002-KV22,RRID:AB_2492211
Antigen/Purification:ExpandCollapse

Theantigenisapeptidefromthesubunitregionofthevoltagegatedpotassiumchannel,Kv2.2ofratandXenopus,conjugatedtokeyholelimpethemocyanin(KLH).

TheantibodyispreparedfrompooledrabbitserumbyaffinitypurificationusingaSulfo-Link®columnmatrixtowhichthepeptideimmunogenwascoupled.

BIOLOGicalSignificance:ExpandCollapse

Voltage-gatedK+channelsareimportantdeterminantsofneuronalmembraneexcitABIlity(Pongs,1999).Moreover,differencesinK+channelexpressionpatternsanddensitiescontributetothevariationsinactionpotentialwaveformsandrepetitivefiringpatternsevidentindifferentneuronalcelltypes.Thedelayedrectifier-type(IK)channels(Kv1.5,Kv2.1,andKv2.2)areexpressedonallneuronalsomataandproximaldendritesandarealsofoundinawidevarietyofnon-neuronalcellstypesincludingpancreaticislets,alveolarcellsandcardiacmyocytes(Hwangetal.,1993;Yanetal.,2004;Michaelevskietal.,2003).Kv2.1andKv2.2formdistinctpopulationsofK+channelsandthesesubunitsarethoughttobeprimarilyresponsIBLeforIKinsuperiorcervicalganglioncells(BlaineandRibera,1998;BurgerandRibera,1996).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

Product SpecificReferences

Gravagna,N.G.,Knoeckel,C.S.,Taylor,A.D.,Hultgren,B.A.andRibera,A.B.,2008.LocalizationofKv2.2proteininXenopuslaevisembryosandtadpoles.JournalofComparativeNeurology,510(5),pp.508-524.PMID:18680201

D.Guan,T.Tkatch,D.J.Surmeier,W.E.Armstrong,andR.C.Foehring(2007)Kv2subunitsunderlieslowlyinactivatingpotassiumcurrentinratneocorticalpyramidalneurons
J.Physiol.,Jun2007;581:941–960.PMID:17379638

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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