Rabbitpolyclonalantibody
PooledSerum- Size:
- 100µl
- Formulation:
- AffinityPurifiedfromPooledSerum
- Specificity:
- Rat,Mouse,Human,Bovine,Non-humanprimate,Sheep,Canine
- Applications:
- WB1:250
- Species:
- Rabbit
- GeneName:
- BECN1
- MolecularReference:
- ~60kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#p117-234,RRID:AB_2492047
Antigen/Purification:Collapse
Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser234ofhumanbeclin-1.
Theantibodyispreparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.
BIOLOGicalSignificance:Collapse
Beclin-1playsakeyroleintumorsuppressionandautophagy.Ithasbeensuggestedthatautophagyproteinssuchasbeclin-1caninhibittumOrigenesisandthatdecreasedexpressionoftheseproteinsmaycontributetothedevelopmentofhumanmalignancies(Liangetal.,1999).Beclin-1hasbeenshowntointeractwith14-3-3proteinsthroughAkt-mediatedphosphorylationatSer234(Wangetal.,2012).
Storage
100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.
Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.
ProductSpecificReferences
RichardC.Wang,YongjieWei,ZhenyiAn,ZhongjuZou,GuanghuaXiao,GovindBhagat,MichaelWhite,JuliaReichelt,andBethLevine(2012)Akt-MediatedRegulationofAutophagyandTumorigenesisThroughBeclin1Phosphorylation.Science338:956-959.PMID:23112296
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik，他们在 Paul Greengard 博士的实验室共同工作，Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区，是一支敬业、友好、勤奋的科学家团队，致力于为您提供最优质的抗体和业内客户支持。
本网站将在规定时间内给予删除等相关处理。
