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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/ATF2 (Ser490,498) Antibody/p115-4908/100 µl
产品编号:p115-4908
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/ATF2 (Ser490,498) Antibody/p115-4908/100 µl
商品介绍

Rabbitpolyclonalantibody

Size:
100µl
Formulation:
Affinitypurified
Specificity:
Rat,Human
Applications:
WB1:1000IHC1:1000
Species:
Rabbit
MolecularReference:
~74kDa
CiteThisAntibody:
PhosphoSolutionsCat#p115-4908,RRID:AB_2492044
Antigen/Purification:ExpandCollapse

Theantigenisasyntheticphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser490,498ofhumanATF2.

Theantibodyispreparedfromrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

TheactivatingtranscriptionfactorATF2(alsocalledCRE-BP1)bindstobothAP-1andCREDNAresponseelementsandisamemberoftheATF/CREBfamilyofleucinezipperproteins(Maekawaetal.,1989).ATF2hasbeenimplicatedinthetranscriptionalregulationofanumberofgenesincludingcytokines,cellcyclecontrolandapoptosis.Variousformsofcellularstress,includinginflammatorycytokinesandUVirrADIation,stimulatethetranscriptionalactivityofATF2(Ivanovetal.,2003;Mortonetal.,2004).StressinducedATFdependenttranscriptionisdependentonphosphorylationofATF(Fuchsetal.,2000);Mortonetal.,2004).Serine490andserine498arenovelphosphorylationsitesonATFthathaverecentlybeenidentified.ATF2isparticularlyabundantinthebrainandtheATF2familyoftranscriptionfactorsisconsideredanimportantsubstrateofsignalsupstreamoftheactivationofgenesassociatedwithneuronalgrowthanddifferentiation(KarinandHunter,1995).ATFexpressionhasalsobeenlinkedtothedepressioninhumans(Laifenfeldetal.,2004).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgBSApermland50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

ProductSpecificReferences

Muñoz,DeniseP.,MisakoKawahara,andStevenM.Yannone.“Anautonomouschromatin/DNA-PKmechanismforlocalizedDNAdamagesignalinginmammaliancells.”Nucleicacidsresearch41.5(2013):2894-2906.PMID:23325849

BhoumikA,TakahashiS,BreitweiserW,ShilohY,JonesN,RonaiZ(2005)ATM-dependentphosphorylationofATF2isrequiredforDNAdamageresponse.MolCellMay27;18(5):577-87.PMID:15916964

 

 

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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