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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Retinoic Acid Receptor Antibody, α-Isotype, Human/1330-RXRA/100 µl
产品编号:1330-RXRA
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Retinoic Acid Receptor Antibody, α-Isotype, Human/1330-RXRA/100 µl
商品介绍

Mousemonoclonalantibody

Size:
100µl
Formulation:
ProteinGPurified
Specificity:
Rat,Mouse,Human,Bovine,Canine,GuineaPig
Applications:
WB1:1,000
Species:
Mouse
MolecularReference:
~48kDa
CiteThisAntibody:
PhosphoSolutionsCat#1330-RXRA,RRID:AB_2492228
Antigen/Purification:ExpandCollapse

TheantigenisapeptidecorrespondingtoaminoacidresiduesfromtheN-terminalregionofhumanretinoicacidreceptor,α-isotype.

TheantibodyispreparedfrommouseascitesbyammoniumsulfateprecipitationfollowedaffinitypurificationonaProteinGcolumn.

BIOLOGicalSignificance:ExpandCollapse

Retinoicacid(RA;activemetaboliteofvitaminA)playsaprominentroleinregulatingthetransitionofproliferatingprecursorcells(suchascarcinomacellsandneuronalprecursors)topostmitoticdifferentiatedcells(Joshietal.,2005).TheretinoidXreceptors(RXRs)family(RXRα,βandγ),preferentiallybind9-cis-RAandregulategenetranscriptionbyformingheterodimerswithasecondfamilyofRAreceptors.RAshavebeensuggestedtopotentiallyplayatherapeuticroleincervicalcancer(Abuetal.,2005).RAsareknowntoplaykeyrolesinneuronaldevelopmentandanincreasingbodyofevidenceindicatesthatretinoidsignalingmayregulatesynapticplasticityandassociatedlearningandmemorybehaviors(LaneandBailey,2005).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

AbuJ,BatuwangalaM,HerbertK,SymondsP(2005)Retinoicacidandretinoidreceptors:potentialchemopreventiveandtherapeuticroleincervicalcancer.LancetOncol6:712-720.

JoshiS,GuleriaR,PanJ,DipetteD,SinghUS(2005)Retinoicacidreceptorsandtissue-trans-glutaminasemediateshort-termeffectofretinoicacidonmigrationandinvasionofneuroblastomaSH-SY5Ycells.Oncogeneadvanceonlinepublication12September2005;doi:10.1038/sj.onc.1209027.

LaneMA,BaileySJ(2005)Roleofretinoidsignallingintheadultbrain.ProgNeurobiol75:275-293.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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