Rabbitpolyclonalantibody
Theantigenisa syntheticpeptidetakenfromtheC-terminusofratclavesin1.
Theantibodyispreparedfromserumbyaffinitypurificationusingacolumntowhichthepeptideantigenwascoupled.
Clavesin(clathrinvesicleassociatedSec14protein)isanovelneuronspecificproteinthathasrecentlybeenidentifiedandshowntoberequiredfornormalmorphologyoflateendosomesand/orlysosomesaslentiviral-mediatedknockdownofclavesininhippocampalneuronscauseslysosomaldefects(Katohetal.,2009).Additionally,upregulationofclavesininhumanhepatocellularcarcinomahasrecentlybeendemonstratedthusmakingitausefulMarkerforthisdiseasestate(Zhaoetal.,2008).
100µlinPBS+50%glycerol.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1yearafterdateofreceipt.Avoidfreeze/thawcycles.
YoheiKatoh,BrigitteRitter,ThomasGaffry,FrancoisBlondeau,StefanHöningandPeterS.McPherson(2009)theclavesinfamily:neuron-specificlipid-andclathrin-bindingSec14proteinsregulatinglysosomalmorphology.JournalofBiologicalChemistryOct2;284(40):27646-54.
ZhaoS,XuC,QianH,LvL,JiC,ChenC,ZhaoX,ZhengD,GuS,XieY,MaoY(2008)Cellularretinaldehyde-bindingprotein-like(CRALBPL),anovelhumanSec14p-likegenethatisupregulatedinhumanhepatocellularcarcinomas,maybeusedasamarkerforhumanhepatocellularcarcinomas.DNACellBiol.Mar;27(3):159-63.
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。