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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/RBPMS Antibody, Rabbit/1830-RBPMS/100 µl
产品编号:1830-RBPMS
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/RBPMS Antibody, Rabbit/1830-RBPMS/100 µl
商品介绍

Rabbitpolyclonalantibody

Size:
100µl
Formulation:
Affinitypurified
Specificity:
Rat,Mouse,Human,Non-humanprimate,Rabbit,GuineaPig
Applications:
WB1:1,000IHC1:500
Species:
Rabbit
GeneName:
RBPMS
MolecularReference:
~24kDa
CiteThisAntibody:
PhosphoSolutionsCat#1830-RBPMS,RRID:AB_2492225
Antigen/Purification:ExpandCollapse

TheantigenisasyntheticpeptidecorrespondingtoaminoacidresiduesfromtheN-terminalregionoftheratRBPMSsequenceconjugatedtoKLH.

Theantibodyispreparedfromrabbitserumbyaffinitypurificationviachromatographyonanaffinitycolumnpreparedwiththepeptideusedasantigen.

BIOLOGicalSignificance:ExpandCollapse

RBPMS(RNAbindingproteinwithmultiplesplicing),alsoknownasHERMES,containsoneRRM(RNArecognitionmotif)domainandbelongstotheRRMfamilyofRNA-bindingproteins.RBPMSexistsasmultiplealternativelysplicedisoformsandisthoughttobindRNA,possIBLyplayingaroleinRNA-relatedevents,suchastranscriptionandtranslation.RNA-bindingproteinsthatarespecifictoretinalganglioncells(RGCs)havebeenpreviouslyidentifiedasexcellentMarkersforRGCs(Kwongetal.,2010).RecentfindingsshowthatantibodiesagainstRBPMSarerobustreagentsthatexclusivelyidentifyRGCsinmultiplemammalianspecies(Rodriguezetal.2014)

Storage

100µlinPBS+0.03%sodiumazide.

Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.

ProductSpecificReferences

Livne-Bar,I.,Wei,J.,Liu,H.H.,Alqawlaq,S.,Won,G.J.,Tuccitto,A.,Gronert,K.,Flanagan,J.G.andSivak,J.M.,2017.Astrocyte-derivedlipoxinsA4andB4promoteneuroprotectionfromacuteandchronicinjury.TheJournalofClinicalInvestigation,127(12).PMID:29106385

Apara,A.,Galvao,J.,Wang,Y.,Blackmore,M.,Trillo,A.,Iwao,K.,Brown,D.P.,Fernandes,K.A.,Huang,A.,Nguyen,T.andAshouri,M.,2017.KLF9andJNK3InteracttoSuppressAxonRegenerationintheAdultCNS.JournalofNeuroscience,pp.0643-16.PMID:28871032

Chiasseu,M.,Alarcon-Martinez,L.,Belforte,N.,Quintero,H.,Dotigny,F.,Destroismaisons,L.,Velde,C.V.,Panayi,F.,Louis,C.andDiPolo,A.,2017.TauaccumulationintheretinapromotesearlyneuronaldysfunctionandprecedesbrainpathologyinamousemodelofAlzheimer’sdisease.MolecularNeurodegeneration,12(1),p.58.PMID:28774322

Assali,A.,LeMagueresse,C.,Bennis,M.,Nicol,X.,Gaspar,P.andRebsam,A.,RIM1/2arerequiredinretinalganglioncellsfortherefinementofipsilateralaxonsandeye-specificsegregation.ScientificReports.2017,Jun12. PMID:28607399

Joly,S.,Lamoureux,S.andPernet,V.,2017.Non-amyloidogenicprocessingofamyloidbetaprecursorproteinisassociatedwithretinalfunctionimprovementinagingmaleAPPswe/PS1ΔE9mice.NeurobiologyofAging. 2017May;53:181-191.PMID:28262325

Liddelow,S.A.,Guttenplan,K.A.,Clarke,L.E.,Bennett,F.C.,Bohlen,C.J.,Schirmer,L.,Bennett,M.L.,Münch,A.E.,Chung,W.S.,Peterson,T.C.andWilton,D.K.,2017.Neurotoxicreactiveastrocytesareinducedbyactivatedmicroglia.Nature.2017Jan26;541(7638):481-487.PMID:28099414

Hunt,N.C.,Hallam,D.,Karimi,A.,Mellough,C.B.,Chen,J.,Steel,D.H.andLako,M.,2016.3DcultureofhumanpluripotentstemcellsinRGD-alginatehydrogelimprovesretinaltissuedevelopment.ActaBiomaterialia. 2017Feb;49:329-343. PMID:27826002

Chen,L.andGage,P.J.,2016.HeterozygousPitx2NullMiceAccuratelyRecapitulatetheOcularFeaturesofAxenfeld-RiegerSyndromeandCongenitalGlaucoma.InvestigativeOphthalmology&VisualScience,57(11),pp.5023-5030.PMID:27654429

Lim,J.H.A.,Stafford,B.K.,Nguyen,P.L.,Lien,B.V.,Wang,C.,Zukor,K.,He,Z.&Huberman,A.D.(2016).Neuralactivitypromoteslong-distance,target-specificregenerationofadultretinalaxons.NatureNeuroscience.2016Aug;19(8):1073-84.PMID:27399843

Vargas,J.L.C.,Belforte,N.,&DiPolo,A.(2016).TheglialcellmodulatoribudilastattenuatesneuroinflammationandenhancesretinalganglioncellviABIlityinglaucomathroughproteinkinaseAsignaling.Neurobiologyofdisease,93,156-171.PMID:27163643

Shabanzadeh,A.P.,D’onofrio,P.M.,Monnier,P.P.,&Koeberle,P.D.(2015).Targetingcaspase-6andcaspase-8topromoteneuronalsurvivalfollowingischemicstroke.Celldeath&disease,6(11),e1967.PMID:26539914

Vargas,J.L.C.,Osswald,I.K.,Unsain,N.,Aurousseau,M.R.,Barker,P.A.,Bowie,D.,&DiPolo,A.(2015).SolubleTumorNecrosisFactorAlphaPromotesRetinalGanglionCellDeathinGlaucomaviaCalcium-PermeableAMPAReceptorActivation.TheJournalofNeuroscience,35(35),12088-12102.PMID:26338321

Reifler,A.N.,Chervenak,A.P.,Dolikian,M.E.,Benenati,B.A.,Meyers,B.S.,Demertzis,Z.D.,Lynch,A.M.,Li,B.Y.,Wachter,R.D.,Abufarha,F.S.,Dulka,E.A.,Pack,W.,Zhao,X.,&Wong,K.Y.(2015).Theratretinahasfivetypesofganglion-cellphotoreceptors.Experimentaleyeresearch,130,17-28.PMID:25450063

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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