Mousemonoclonalantibody
- Size:
- 100µl
- Formulation:
- ProteinGPurified
- Specificity:
- Mostmammals
- Applications:
- WB1:1,000IHC1:100
- Species:
- Mouse
- MolecularReference:
- ~39kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#1840-RHO,RRID:AB_2492232
Antigen/Purification:Collapse
Theantigenisabovinerhodopsin.
TheantibodyisProteinGpurifiedculturesupernatant.
BIOLOGicalSignificance:Collapse
Rhodopsinisaphotoreceptorproteinfoundinretinalrods.Itisacomplexformedbythebindingofretinaldehyde,theoxidizedformofretinol,totheproteinopsinandundergoesaseriesofcomplexreactionsinresponsetovisIBLelightresultinginthetransmissionofnerveimpulsestothebrain.Mutationoftherhodopsingeneisamajorcontributortovariousretinopathiessuchasretinitispigmentosa.Thedisease-causingproteingenerallyaggregateswithubiquitinininclusionbodies,disruptstheintermediatefilamentnetworkandimpairstheABIlityofthecelltodegradenon-functioningproteinswhichleadstophotoreceptorapoptosis(Bersonetal.,1991).OthermutationsonrhodopsinleadtoX-linkedcongenitalstationarynightblindness,mainlyduetoconstitutiveactivation,whenthemutationsoccuraroundthechromophorebindingpocketofrhodopsin(Dryjaetal.,1993).Severalotherpathologicalstatesrelatingtorhodopsinhavebeendiscoveredincludingpoorpost-Golgitrafficking,dysregulativeactivation,rodoutersegmentinstabilityandarrestinbinding.
Storage
100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternblots.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
ProductSpecificReferences
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik，他们在 Paul Greengard 博士的实验室共同工作，Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区，是一支敬业、友好、勤奋的科学家团队，致力于为您提供最优质的抗体和业内客户支持。
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