Mousemonoclonalantibody
Theantigenis asyntheticpeptidefromN-terminalregionofmousenorepinephrinetransporter.
TheantibodyisProteinGpurifiedculturesupernatant.
NorepinephrineTransporter[NET](ornoradrenalinetransporter(NAT))isamonoaminetransporterthattransportstheneurotransmitternoradrenalinefromthesynapsebacktoitsvesiclesforstorageuntillateruse.Italsoappearstotransporttheneurotransmitterdopamineinthesameway,buttoalesserdegree.StudieshaveshownadecreaseinNETlevelsinthelocuscoeruleusinpatientsdiagnosedwithmajordepression(Klimeketal.,1997).Cocaine,amphetaminesandmanytherapeuticantidepressants,suchastheSNRIs(SEROtonin-norepinephrinereuptakeinhibitors)andthetricyclicantidepressants(TCAs)acttoraisenoradrenaline.FurThermore,deficitsintheNETgenehavebeenassociatedwithADHD(Kimetal.,2006).
100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternblots.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforuptooneyearafterdateofreceipt.Avoidfreeze/thawcycles.
Andreoli,M.,Marketkar,T.andDimitrov,E.,2017.ContributionofamygdalaCRFneuronstochronicpain.ExperimentalNeurology,298,pp.1-12.PMID:28830762
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。