Rabbitpolyclonalantibody

Size:

100µl

Formulation:

AffinityPurifiedfromPooledSerum

Specificity:

Mostmammals

Applications:

WB1:1,000IF1:1000IHC1:1000

Species:

Rabbit

GeneName:

TH

MolecularReference:

~60kDa

CiteThisAntibody:

PhosphoSolutionsCat#p1580-40,RRID:AB_2492279

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternblots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

ProductSpecificReferences

Salvatore,M.F.,Terrebonne,J.,Cantu,M.A.,McInnis,T.R.,Venable,K.,Kelley,P.,Kasanga,E.A.,Latimer,B.,Owens,C.L.,Pruett,B.S.andYu,Y.,2017.Dissociationofstriataldopamineandtyrosinehydroxylaseexpressionfromaging-relatedmotordecline:evidencefromcalorierestrictionintervention.JournalsofGerontologySeriesA:BiomedicalSciencesandMedicalSciences,p.glx119.PMID:28637176

Jorge-Finnigan,A.,Kleppe,R.,Jung-KC,K.,Ying,M.,Marie,M.,Rios-Mondragon,I.,Salvatore,M.F.,Saraste,J.andMartinez,A.,2017.Phosphorylationatserine31targetstyrosinehydroxylasetovesiclesfortransportalongmicrotubules.JournalofBiologicalChemistry,pp.jbc-M116.PMID:28637871

Barroso-Chinea,P.,Cruz-Muros,I.,Afonso-Oramas,D.,Castro-Hernández,J.,Salas-Hernández,J.,Chtarto,A.,Luis-Ravelo,D.,Humbert-Claude,M.,Tenenbaum,L.andGonzález-Hernández,T.(2016)Long-termcontrolledGDNFover-expressionreducesdopaminetransporteractivitywithoutaffectingtyrosinehydroxylaseexpressionintheratmesostriatalsystem.NeurobiologyofDisease.88:44-54. PMID:26777664

Bonito-Oliva,A.,Spigolon,G.,&Fisone,G.(2015).RegulationofPre-andPostsynapticProteinPhosphorylationbyDopamineD2Receptors.InDopamineReceptorTechnologies(pp.79-100).SpringerNewYork.

Calipari,E.S.,Ferris,M.J.,Melchior,J.R.,Bermejo,K.,Salahpour,A.,Roberts,D.,&Jones,S.R.(2014).Methylphenidateandcocaineself‐admiNISTrationproducedistinctdopamineterminalalterations.Addictionbiology,19(2),145-155.PMID:22458761

Izumi,Y.,Ezumi,M.,Takada-Takatori,Y.,Akaike,A.,&Kume,T.(2014).Endogenousdopamineisinvolvedintheherbicideparaquat-induceddopaminergiccelldeath.ToxicologicalSciences,139(2),466-478.PMID:24743698

Salvatore,M.F.(2014).ser31tyrosinehydroxylasephosphorylationparallelsdifferencesindopaminerecoveryinnigrostriatalpathwayfollowing6‐OHDAlesion.JournalofneuRochemistry,129(3),548-558.PMID:24410633

McCutcheonJE,ConradKL,CarrSB,FordKA,McGeheeDS,andMarinelliM(2012)Dopamineneuronsintheventraltegmentalareafirefasterinadolescentratsthaninadults.JNeurophysiology108(6):1620-1630.PMID:22723669

MeyerDA,RicherE,BenkovicSA,HayashiK,KansyJW,HaleCF,MoyLY,KimY,O’CallaghanJP,TsaiLH,GreengardP,NairnAC,CowanCW,MillerDB,AntichP,andBibbJA(2008)StriataldysregulationofCdk5alterslocomotorresponsestococaine,motorlearning,anddendriticmorphology.PNAS,105:18561–18566.PMID:19017804

JedynakJP,AliSF,HaycockJW,HopeBT(2002)Acuteadministrationofcocaineregulatesthephosphorylationofserine-19,-31and-40intyrosinehydroxylase.JNeurochem82:382-388.PMID:12124439

SalvatoreMF,WaymireJC,HaycockJW(2001)Depolarization-stimulatedcatecholaminebiosynthesis:involvementofproteinkinasesandtyrosinehydroxylasephosphorylationsitesinsitu.JNeurochem79:349-360.PMID:11677263

WitkovskyP,GabrielR,HaycockJW,MellerE(2000)Influenceoflightandneuralcircuitryontyrosinehydroxylasephosphorylationintheratretina.JChemNeuroanat19:105-116.PMID:10936746

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik，他们在 Paul Greengard 博士的实验室共同工作，Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区，是一支敬业、友好、勤奋的科学家团队，致力于为您提供最优质的抗体和业内客户支持。