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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Doublecortin (DCX) Antibody/451-DCX/100 µl
产品编号:451-DCX
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Doublecortin (DCX) Antibody/451-DCX/100 µl
商品介绍

Mousemonoclonalantibody

Size:
100µl
Formulation:
ProteinGPurified
Specificity:
Rat,Mouse,Human,Bovine
Applications:
WB1:5,000IF1:1,000
Species:
Mouse
MolecularReference:
~35kDaand~45kDa
CiteThisAntibody:
PhosphoSolutionsCat#451-DCX,RRID:AB_2492079
Antigen/Purification:ExpandCollapse

TheantigenisafulllengthrecombinanthumandoublecortinexpressedinandpurifiedfromE.coli.

TheantibodyisProteinGpurifiedfromculturesupernatant.

BIOLOGicalSignificance:ExpandCollapse

Doublecortin,orDCX,isamicrotubuleassociatedproteinthatisexpressedalmostexclusivelyinveryearlyneuronaldevelopment(Brownetal.,2003),makingitanexcellentMarkerfordevelopingneuronalcells.DefectsintheDCXgeneleadtoX-linkedlissencephalywhichischaracterizedbyalackofnormalfoldsonthesurfaceofthebrainresultinginasmoothcerebralcortexcausedbyabnormalmigrationofneuronsduringdevelopment(desPortesetal.,1998;Gleesonetal.,1998).

Storage

100µlinPBS+10mMsodiumazide.

Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.

GeneralReferences

BrownJP,Couillard-DesprésS,Cooper-KuhnCM,WinklerJ,AignerL,KuhnHG(2003)Transientexpressionofdoublecortinduringadultneurogenesis.JCompNeurol.Dec1;467(1):1-10.

desPortesV,PinardJM,BilluartP,VinetMC,KoulakoffA,CarriéA,GelotA,DupuisE,MotteJ,Berwald-NetterY,CatalaM,KahnA,BeldjordCandChellyJ.(1998)AnovelCNSgenerequiredforneuronalmigrationandinvolvedinX-linkedsubcorticallaminarheterotopiaandlissencephalysyndrome.Cell92:51-61.

GleesonJG,AllenKM,FoxJW,LampertiED,BerkovicS,SchefferI,CooperEC,DobynsWB,MinnerathSR,RossMEandWalshCA.(1998)Doublecortin,abrain-specificgenemutatedinhumanX-linkedlissencephalyanddoublecortexsyndrome,encodesaputativesignalingprotein.Cell92:63-72.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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