Mousemonoclonalantibody
TheantigenisrecombinantfulllengthhumanHSP60protein.
TheantibodyisproteinGpurifiedfromculturesupernatant.
HSP60isamemberoftheheatshockproteinfamilywhichisthoughttoplayakeyroleinmitochondrialproteintransportandproperrefoldingofproteinsimportedfromthecytoplasmintothemitochondrialmatrix(Kolletal.,1992). Morerecently,HSP60hasbeenimplicatedinthepathogenesisofcardiovasculardisease(Rizzoetal.,2011).
100µlinPBS+50%glyceroland 5mMsodiumazide.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
KollH,GuiardB,RassowJ,OstermannJ,HorwichAL,NeupertW,HartlFU.(1992) AntifoldingactivityofHSP60couplesproteinimportintothemitochondrialmatrixwithexporttotheintermembranespace. Cell68:1163-75.
RizzoM, MacarioAJ, deMacarioEC, Gouni-BertholdI, BertholdHK, RiniGB, ZummoG, CappelloF.(2011)Heatshockprotein-60andriskforcardiovasculardisease.CurrPharmDes17:3662-8.
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