Mousemonoclonalantibody
TheantigenisarecombinantpartialsegmentofhumannestinexpressedinandpurifiedfromE.coli.
TheantibodyisProteinGpurified.
NestinisamemberoftheclassIVintermediatefilamentproteinfamilywhichisexpressedinneuronalstemcells(Lendahletal.,1990).Nestinwasoriginallyidentifiedasaresultoftheproductionofaseriesofmonoclonalantibodiesdirectedagainstepitopesexpressedonformalinfixedembryoday15ratspinalcord(Hockfieldetal.,1985)).Oneoftheseantibodies,calledRat401,stainedfibrousprofilesinthedevelopingnervoussystem,butnotinthematurenervoussystem.ByscreeningbacteriophageexpressionlibrarieswithRat401,Lendahletal.wereabletoisolateaCDNAencodingtheproteintowhichRat401antibodybound.Theproteinprovedtobeanunusualmemberoftheintermediatefilamentfamily,containinganalpha-helicalregionhomologoustothatfoundinkeratinandneurofilamentsubunits.
Ascitesfluid+0.01%NaN3.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforuptooneyearafterdateofreceipt.Avoidfreeze/thawcycles.
Thakur,V.,Nargis,S.,Gonzalez,M.,Pradhan,S.,Terreros,D.andChattopadhyay,M.,2017.RoleofGlycyrrhizinintheReductionofInflammationinDiabeticKidneyDisease.Nephron.PMID:28641285
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