Chickenpolyclonalantibody
Theantigenisapreparationofbovinespinalcordintermediatefilaments.
TheantibodyistotalIgYfraction.
Neurofilamentsarethe10nmorintermediatefilamentproteinsfoundspecificallyinneurons,andarecomposedpredominantlyofthreemajorproteinscalledNF-L,NF-MandNF-H(1).NF-ListheneurofilamentlightorlowmolecularweightpolypeptideandrunsonSDS-PAGEgelsatabout68kDa.AntibodiestoNF-Lareusefulforidentifyingneuronalcellsandtheirprocessesintissuesectionsandintissueculture.MutationsintheproteincodingregionofthehumanNF-LgenecausesomeformsofCharcot-Marie-Toothdisease(2).
Liquidcontaining10mMsodiumazide.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
Harris,J.,Ayyub,C.andShawG.(1991)AmoleculardissectionofthecarboxyterminaltailsofthemajorneurofilamentsubunitsNF-MandNF-H.JNeurosciRes30:47-62.
MersiyanovaIV,PerepelovAV,PolyakovAV,SitnikovVF,DadaliEL,OparinRB,PetrinANandEvgrafovOV.(2000)AnewvariantofCharcot-Marie-Toothdiseasetype2isprobablytheresultofamutationintheneurofilament-lightgene.Am.J.Hum.Genet.67:37-46.
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。