请使用支持JavaScript的浏览器!
主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Nuclear Pore Complex Antibody/1515-NPC/100 µl
产品编号:1515-NPC
市  场 价:¥3911.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$295.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Nuclear Pore Complex Antibody/1515-NPC/100 µl
商品介绍

Mousemonoclonalantibody

Size:
100µl
Formulation:
TotalIgGfraction
Specificity:
Rat,Mouse,Human,Someinvertebrates
Applications:
IF1:50-1:100
Species:
Mouse
CiteThisAntibody:
PhosphoSolutionsCat#1515-NPC,RRID:AB_2492188
Antigen/Purification:ExpandCollapse

Theantigenisayeastnuclearpreparations.

Theantibodyisconcentratedculturesupernatant.

BIOLOGicalSignificance:ExpandCollapse

Thenuclearporecomplex(NPC)isaverylargestructuremadeupofatleast50differentproteinsthatspanthedoublemembraneofthenuclearenvelopefunctioningasagatewayformacromoleculartrafficbetweenthecytoplasmandthenucleus(NakielnyandDreyfuss,1999).DiscretenuclearporecomplexproteinsornucleoporinssuchasNUP98,NUP180andp62havebeenimplicatedinautoimmunediseaseandcancer.Patientswithprimarybiliarycirrhosis(PBC)frequentlyproduceautoantibodiesagainstp62andNUP180(Wilkenetal.,1993;Nesheretal.,2001)whileNUP98translocationshavebeenfoundinpatientswithacutemyelogenousleukemia(AML)(Jajuetal.2001)

Storage

Liquid.Contains10mMsodiumazide.

Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.

GeneralReferences

NakielnyS,DreyfussG(1999)TransportofproteinsandRNAsinandoutofthenucleus.Cell99(7):677-690.

WilkenN,KossnerU,SenecalJL,ScheerU,DabauvalleMC(1993)Nup180,anovelnuclearporecomplexproteinlocalizingtothecytoplasmicringandassociatedfibrils.JCellBiol123(6pt1):1345-54.

NesherG,MargalitR,AshkenaziYJ(2001)Anti-nuclearenvelopeantibodies:Clinicalassociations.SeminArthritisRheum30(5):313-20.

JajuRJ,FidlerC,HaasOA,StricksonAJ,WatkinsF,ClarkK,CrossNC,ChengJF,AplanPD,KearneyL,BoultwoodJ,WainscoatJS(2001)Anovelgene,NSD1,isfusedtoNUP98inthet(5;11)(q35;p15.5)indenovochildhoodacutemyeloidleukemia.Blood98(4):1264-7.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

自营商城图标
厂家直采
全球直采 正品优价
正品保障图标
正品保障
厂家直发 有线跟踪
解放采购图标
正规清关
CIF100%正规报关,提供发票
及时交付图标
及时交付
限时必达 不达必赔