Mousemonoclonalantibody
Theantigenisayeastnuclearpreparations.
Theantibodyisconcentratedculturesupernatant.
Thenuclearporecomplex(NPC)isaverylargestructuremadeupofatleast50differentproteinsthatspanthedoublemembraneofthenuclearenvelopefunctioningasagatewayformacromoleculartrafficbetweenthecytoplasmandthenucleus(NakielnyandDreyfuss,1999).DiscretenuclearporecomplexproteinsornucleoporinssuchasNUP98,NUP180andp62havebeenimplicatedinautoimmunediseaseandcancer.Patientswithprimarybiliarycirrhosis(PBC)frequentlyproduceautoantibodiesagainstp62andNUP180(Wilkenetal.,1993;Nesheretal.,2001)whileNUP98translocationshavebeenfoundinpatientswithacutemyelogenousleukemia(AML)(Jajuetal.2001)
Liquid.Contains10mMsodiumazide.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
NakielnyS,DreyfussG(1999)TransportofproteinsandRNAsinandoutofthenucleus.Cell99(7):677-690.
WilkenN,KossnerU,SenecalJL,ScheerU,DabauvalleMC(1993)Nup180,anovelnuclearporecomplexproteinlocalizingtothecytoplasmicringandassociatedfibrils.JCellBiol123(6pt1):1345-54.
NesherG,MargalitR,AshkenaziYJ(2001)Anti-nuclearenvelopeantibodies:Clinicalassociations.SeminArthritisRheum30(5):313-20.
JajuRJ,FidlerC,HaasOA,StricksonAJ,WatkinsF,ClarkK,CrossNC,ChengJF,AplanPD,KearneyL,BoultwoodJ,WainscoatJS(2001)Anovelgene,NSD1,isfusedtoNUP98inthet(5;11)(q35;p15.5)indenovochildhoodacutemyeloidleukemia.Blood98(4):1264-7.
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。