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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Ubiquitin C-terminal Hydrolase 1 (PGP9.5) Antibody, Mouse/2060-UCHL1/100 µl
产品编号:2060-UCHL1
市  场 价:¥3911.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$295.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Ubiquitin C-terminal Hydrolase 1 (PGP9.5) Antibody, Mouse/2060-UCHL1/100 µl
商品介绍

Mousemonoclonalantibody

Size:
100µl
Formulation:
ProteinGPurified
Specificity:
Rat,Mouse,Human,Bovine
Applications:
WB1:5,000IF1:500
Species:
Mouse
MolecularReference:
~24kDa
CiteThisAntibody:
PhosphoSolutionsCat#2060-UCHL1,RRID:AB_2492280
Antigen/Purification:ExpandCollapse

Theantigenisa  recombinantfulllengthhumanUCHL1purifiedfromE.coli.

TheantibodyisproteinGpurifiedculturesupernatant.

BIOLOGicalSignificance:ExpandCollapse

UbiquitinC-terminalhydrolase1(UCHL1)isalsoknownasubiquitincarboxylesteraseL1,ubiquitinthiolesterase,neuron-specificproteinPGP9.5andPark5.Itwasoriginallyidentifiedasamajorcomponentoftheneuronalcytoplasmfrom2-dimensionalgelanalysisofbraintissues,andwasgiventhenamePGP9.5(1).ItwaslaterfoundthatubiquitinC-terminalhydrolaseenzymeactivitywasassociatedwiththePGP9.5protein(2).TheubiquitinC-terminalhydrolasescleaveubiquitinfromothermolecules.Regulationoftheubiquitinpathwayisveryimportantandmanydiseasestatesareassociatedwithdefectsinthispathway.GeneticknockoutofUCHL1inmiceresultsinamotorneurondegenerationsimilartothespontaneousgracileaxonaldystrophy(gad)mutantmice(3).PointmutationsintheUCHL1geneareassociatedwithsomeformsofhumanParkinson’sdisease(4).SinceUCHL1isheavilyexpressedinneurons,itisreleasedinlargeamountsfollowinginjuryordegeneration,sothedetectionofUCHL1inCSFandotherbodilyfluidscanbeusedasabioMarker.

Storage

Liquid.Contains10mMsodiumazide.

Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.

GeneralReferences

DoranJF,JacksonP,KynochPA,ThompsonRJ.IsolationofPGP9.5,anewhumanneurone-specificproteindetectedbyhigh-resolutiontwo-dimensionalelectrophoresis.JNeuRochem.40:1542-7(1983).

WilkinsonKD,LeeKM,DeshpandeS,Duerksen-HughesP,BossJM,PohlJ.TheneuronspecificproteinPGP9.5isaubiquitincarboxyl-terminalhydrolase.Science.1989246:670-3(1989).

KuriharaLJ,KikuchiT,WadaK,TilghmanSM.LossofUch-L1andUch-L3leadstoneurodegeneration,posteriorparalysisanddysphagia.HumMolGenet.10:1963-70(2001).

LiuY,FallonL,LashuelHA,LiuZ,LansburyPTJr.TheUCH-L1geneencodestwoopposingenzymaticactivitiesthataffectalpha-synucleindegradationandParkinson’sdiseasesusceptibility.Cell111:209-18(2002).

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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