Mousemonoclonalantibody
TheantigenisrecombinantfulllengthhumanVSNL1expressedinandpurifiedfromE.Coli.
TheantibodyisProteinGpurifiedculturesupernatant.
Visinin-likeprotein1(VSNL1),alsoknownasVILIP1,isacalciumsensorproteinexpressedexclusivelyinneurons.HighestlevelsofVSNL1expressionarefoundincerebellarPurkinjecells.VSNL1hasbeenimplicatedinthemodulationofcellsignalingcascadesviaregulationofadenylcyclaseactivity(Braunewelletal.,1997).Additionally,VSNL1hasbeenassociatedwithamyloidplaquesandneurofibrillartanglesinAlzheimer’sdisease(Schnurraetal.,2001).
100ulliquidcontaining10mMsodiumazide.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
BraunewellKH,SpilkerC,BehnischT,GundelfingerED(1997)Theneuronalcalcium-sensorproteinVILIPmodulatescyclicAMPaccumulationinstablytransfectedC6gliomacells:amino-terminalmyristoylationdeterminesfunctionalactivity.J.NeuRochem.68(5):2129–39.
SchnurraI,BernsteinHG,RiedererP,BraunewellKH(2002)TheneuronalcalciumsensorproteinVILIP-1isassociatedwithamyloidplaquesandextracellulartanglesinAlzheimer’sdiseaseandpromotescelldeathandtauphosphorylationinvitro:alinkbetweencalciumsensorsandAlzheimer’sdisease?Neurobiol.Dis.8(5):900–9.
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。