PhosphoSolutions/Metabotropic Glutamate Receptor 2/3 Antibody/2030-mGluR2/3/100 µl,PhosphoSolutions,,PhosphoSolutions,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：PhosphoSolutions/Metabotropic Glutamate Receptor 2/3 Antibody/2030-mGluR2/3/100 µl

产品编号：2030-mGluR2/3

市场价：¥4574.70

场地：美国(厂家直采)

产品分类：抗体类>一抗>功能性抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$345.00

品牌： PhosphoSolutions

公司：PhosphoSolutions

公司分类：

商品介绍

Rabbitpolyclonalantibody

Size:: 100µl
Formulation:: Affinitypurified
Specificity:: Rat,Mouse,Human,Bovine,Non-humanprimate,Zebrafish,Canine
Applications:: WB1:1,000IHC1:500
Species:: Rabbit
GeneName:: GRM2/3
MolecularReference:: ~110kDaand~220kDa
CiteThisAntibody:: PhosphoSolutionsCat#2030-mGluR2/3,RRID:AB_2492151

Antigen/Purification:ExpandCollapse

TheantigenisapeptidefromtheC-terminalregionofratmGluR2andratmGluR3.

Theantibodyispreparedfromrabbitserumbyaffinitypurificationusingacolumntowhichthepeptideimmunogenwascoupled.

BIOLOGicalSignificance:ExpandCollapse

Themetabotropicglutamatereceptors(mGluRs)arekeyreceptorsinthemodulationofexcitatorysynaptictransmissioninthecentralnervoussystem.Theyareimplicatedinmanyformsofneuralplasticityaswellaslearningandmemoryanddrugabuse(Bhattacharyaetal.,2004;Francesconietal.,2004;WilsonandNicoll,2001).GroupImetabotropicglutamatereceptors(consistingofmGluR1andmGluR5)areG-protein-coupledneurotransmitterreceptorsthatarelocalizedintheperisynapticregionofthepostsynapticmembrane.Whenactivated,GroupImGluRsleadtostimulationofphospholipaseandactivationofProteinKinaseC.Incontrast,activationofGroupIImetabotropicreceptors(mGluR2andmGluR3)leadstoinhibitionofadenylatecyclase.ThemGluR2subunithasbeenshowntoberequiredforlong-termpotentiationatthemossyfiberinputinthehippocampus(Yokoietal.,1996).

Storage

100µlin200mMTris-Glycine(pH7.5),0.1%sodiumazide.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

BhattacharyaM,BabwahAV,GodinC,AnborghPH,DaleLB,PoulterMO,FergusonSSG(2004)RalandphospholipaseD2-dependentpathwayforconstitutivemetabotropicglutamatereceptorendocytosis.JNeurosci24:8752-8761.

FrancesconiW,CammalleriM,SannaPP(2004)Themetabotropicglutamatereceptor5isnecessaryforlate-phaselong-termpotentiationinthehippocampalCA1region.BrainRes1022:12-18.

WilsonRI,NicollRA(2001)EndogenouscannABInoidsmediateretrogradesignallingathippocampalsynapses.Nature(London)410:588-592.

YokoiM,KobayashiK,ManabeT,TakahashiT,SakaguchiI,KatsuuraG,ShigemotoR,OhishiH,NomuraS,NakamuraK,NakaoK,KatsukiM,NakanishiS(1996)ImpairmentofhippocampalmossyfiberLTDinmicelackingmGluR2.Science273:645-647.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik，他们在 Paul Greengard 博士的实验室共同工作，Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区，是一支敬业、友好、勤奋的科学家团队，致力于为您提供最优质的抗体和业内客户支持。

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