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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/Metabotropic Glutamate Receptor 5/1a Antibody/2032-mGluR5/1/100 µl
产品编号:2032-mGluR5/1
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/Metabotropic Glutamate Receptor 5/1a Antibody/2032-mGluR5/1/100 µl
商品介绍

Rabbitpolyclonalantibody

Size:
100µl
Formulation:
Affinitypurified
Specificity:
Rat,Mouse,Human
Applications:
WB1:1,000IHC1:500
Species:
Rabbit
GeneName:
GRM5
MolecularReference:
~125kDaand~250kDa
CiteThisAntibody:
PhosphoSolutionsCat#2032-mGluR5/1,RRID:AB_2492152
Antigen/Purification:ExpandCollapse

TheantigenisapeptidefromtheC-terminalregionofratmGluR5andratmGluR1a.

Theantibodyispreparedfromrabbitserumbyaffinitypurificationusingacolumntowhichthepeptideimmunogenwascoupled.

BIOLOGicalSignificance:ExpandCollapse

Themetabotropicglutamatereceptors(mGluRs)arekeyreceptorsinthemodulationofexcitatorysynaptictransmissioninthecentralnervoussystem.Theyareimplicatedinmanyformsofneuralplasticityaswellaslearningandmemoryanddrugabuse(Bhattacharyaetal.,2004;Francesconietal.,2004;WilsonandNicoll,2001).GroupImetabotropicglutamatereceptors(consistingofmGluR1andmGluR5)areG-protein-coupledneurotransmitterreceptorsthatarelocalizedintheperisynapticregionofthepostsynapticmembrane.Whenactivated,GroupImGluRsleadtostimulationofphospholipaseandactivationofProteinKinaseC.Incontrast,activationofGroupIImetabotropicreceptors(mGluR2andmGluR3)leadstoinhibitionofadenylatecyclase.ThemGluR1receptormayalsobecriticallyinvolvedinlimitingthedeleteriouseffectsofexcitotoxicity(Blaabjergetal.,2003).Incontrast,themGluR5receptorappearstobeessentialforlatephaseLTPinareaCA1ofthehippocampus(Francesconietal.,2004).

Storage

100µlin200mMTris-Glycine(pH7.5),0.1%sodiumazide.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

BhattacharyaM,BabwahAV,GodinC,AnborghPH,DaleLB,PoulterMO,FergusonSSG(2004)RalandphospholipaseD2-dependentpathwayforconstitutivemetabotropicglutamatereceptorendocytosis.JNeurosci24:8752-8761.

BlaabjergM,FangLW,ZimmerJ,BaskysA(2003)NeuroprotectionagainstNMDAexcitotoxicitybygroupImetabotropicglutamatereceptorsisassociatedwithreductionofNMDAstimulatedcurrents.ExpNeurol183:573-580.

FrancesconiW,CammalleriM,SannaPP(2004)Themetabotropicglutamatereceptor5isnecessaryforlate-phaselong-termpotentiationinthehippocampalCA1region.BrainRes1022:12-18.

WilsonRI,NicollRA(2001)EndogenouscannABInoidsmediateretrogradesignallingathippocampalsynapses.Nature(London)410:588-592.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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