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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/mGluR7 (Ser862) Antibody/p1230-862/100 µl
产品编号:p1230-862
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/mGluR7 (Ser862) Antibody/p1230-862/100 µl
商品介绍

Rabbitpolyclonalantibody

Size:
100µl
Formulation:
Affinitypurified
Specificity:
Rat,Mouse,Human,Bovine,Non-humanprimate,Zebrafish,Canine
Applications:
WB1:1,000
Species:
Rabbit
GeneName:
GRM7
MolecularReference:
~102kDa
CiteThisAntibody:
PhosphoSolutionsCat#p1230-862,RRID:AB_2492153
Antigen/Purification:ExpandCollapse

Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingphospho-Ser862ofratmGluR7.

Theantibodyispreparedfromrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptidecolumns.

BIOLOGicalSignificance:ExpandCollapse

Metabotropicglutamatereceptors(mGluRs)arekeyreceptorsinthemodulationofexcitatorysynaptictransmissioninthecentralnervoussystem.Theyareimplicatedinmanyformsofneuralplasticityaswellaslearningandmemoryanddrugabuse(Bhattacharyaetal.,2004;Francesconietal.,2004;WilsonandNicoll,2001).ThemGluRsaredividedintothreegroupsbasedonsequenceidentityandpharmacologicalproperties:groupI(mGluR1andmGluR5)arelocalizedintheperisynapticregionofthepostsynapticmembrane,whereasgroupII(mGlur2andmGluR3)andgroupIII(mGluR4,6,7and8)arelocalizedpredominantlyatpresynapticterminals.PKCphosphorylationofserine862onmGluR7hasbeenshowntobecriticalforstABIlizingreceptorsurfaceexpressionandpromotingbindingtothesynapticPDZ-domain-containingproteinPICK1(Suhetal.,2008).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgBSApermland50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

BhattacharyaM,BabwahAV,GodinC,AnborghPH,DaleLB,PoulterMO,FergusonSSG(2004)RalandphospholipaseD2-dependentpathwayforconstitutivemetabotropicglutamatereceptorendocytosis.JNeurosci24:8752-8761.

FrancesconiW,CammalleriM,SannaPP(2004)Themetabotropicglutamatereceptor5isnecessaryforlate-phaselong-termpotentiationinthehippocampalCA1region.BrainRes

WilsonRI,NicollRA(2001)Endogenouscannabinoidsmediateretrogradesignallingathippocampalsynapses.Nature(London)410:588-592.

SuhYH,PelkeyKA,LavezzariG,RochePA,HuganirRL,McBainCJ,RocheKW.(2008)CorequirementofPICK1bindingandPKCphosphorylationforstablesurfaceexpressionofthemetabotropicglutamatereceptormGluR7.Neuron.58(5):736-48

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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