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主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/NMDA Receptor NR2C Subunit (Ser1244) Antibody/p1518-1244/100 µl
产品编号:p1518-1244
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/NMDA Receptor NR2C Subunit (Ser1244) Antibody/p1518-1244/100 µl
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Rat,Mouse,Human,Bovine,Non-humanprimate,Canine
Applications:
WB1:1,000
Species:
Rabbit
GeneName:
GRIN2C
MolecularReference:
~140kDa
CiteThisAntibody:
PhosphoSolutionsCat#p1518-1244,RRID:AB_2492186
Antigen/Purification:ExpandCollapse

Theantigenisasyntheticphospho-peptidesurroundingthephosphoSer1244oftheNR2C-subunitofratNMDAreceptor.

Theantibodyispreparedfromrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

TheionchannelsactivatedbyglutamatethataresensitivetoN-methyl-Daspartate(NMDA)aredesignatedNMDAreceptors(NMDAR).TheNMDARplaysanessentialroleinmemory,neuronaldevelopmentandithasalsobeenimplicatedinseveraldisordersofthecentralnervoussystemincludingAlzheimer’s,epilepsyandischemicneuronalcelldeath(Grosshansetal.,2002;Wentholdetal.,2003;CarrollandZukin,2002).TheNMDAreceptorisalsooneoftheprincipalmoleculartargetsforalcoholintheCNS(Lovingeretal.,1989;Alvestadetal.,2003;Snelletal.,1996).TheNMDARisalsopotentiatedbyproteinphosphorylation(Luetal.,1999).TheNR2CsubunitofthereceptoristhoughttoinfluencetheNMDARconductancelevel(Ebralidzeetal.,1996).PhosphorylationofSer1244hasbeenshowntoregulateNMDAreceptorchannelfunction(Chenetal.,2006).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

References

AlvestadRM,GrosshansDR,CoultrapSJ,NakazawaT,YamamotoT,BrowningMD(2003)TyrosinedephosphorylationandethanolinhibitionofN-methyl-D-aspartatereceptorfunction.JBiolChem278:11020-11025.

CarrollRC,ZukinRS(2002)NMDA-receptortraffickingandtargeting:implicationsforsynaptictransmissionandplasticity.TrendsNeurosci25:571-577.

EbralidzeAK,RossiDJ,TonegawaS,SlaterNT(1996)ModificationofNMDAreceptorchannelsandsynaptictransmissionbytargeteddisruptionoftheNR2Cgene.JNeurosci16:5014-5025.

GrosshansDR,ClaytonDA,CoultrapSJ,BrowningMD(2002)LTPleadstorapidsurfaceexpressionofNMDAbutnotAMPAreceptorsinadultratCA1.NatNeurosci5:27-33.

LovingerDM,WhiteG,WeightFF(1989)EthanolinhibitsNMDA-activatedioncurrentinhippocampalneurons.Science243:1721-1724.

LuW-Y,XiongZ-G,LeiS,OrserBA,BrowningMD,MacDonaldJF(1999)G-proteincoupledreceptorsactviaproteinkinaseCandSrctoregulateNMDAreceptors.NatureNeurosci2:331-338.

SnellLD,NunleyKR,LickteigRL,BrowningMD,TabakoffB,HoffmanPL(1996)RegionalandsubunitspecificchangesinNMDAreceptormRNAandimmunoreactivityinmousebrainfollowingchronicethanolingestion.MolBrainRes40:71-78.

WentholdRJ,PrybylowskiK,StandleyS,SansN,PetraliaRS(2003)TraffickingofNMDAreceptors.AnnuRevPharmacolToxicol43:335-358.

ChenB,BraudS,BadgerJD,Isaac,JTR,Roche,KW(2006)RegulationofNR1/NR2CN-Methyl-D-aspartate(NMDA)receptorsbyphosphorylation.JBiolChem281:16583-16590.

Note:Dr.MichaelBrowning,aco-authoroffourofthecitedpapers,isPresidentandfounderofPhosphoSolutions.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

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