Rabbitpolyclonalantibody
TheantigenisarecombinantmouseOlig2.
TheantibodyisProteinApurifiedrabbitserum.
Olig2isatranscriptionfactorwhichisrequiredforoligodendrocyteandmotorneuronspecificationinthespinalcord,aswellasforthedevelopmentofsomaticmotorneuronsinthehindbrain.Expressedintheventralspinalcordasearlyas9.5dpcandscatteredinthemantlezone,likelycorrespondingtooligodendrocyteProgenitorsmigratingoutfromtheirsiteoforigin.From10.5through14.5dpc,Olig2isexpressedinnumerouscellsintheventricularandsubventricularzonesofthelateralandmedialganglioniceminences,suggestingthatexpressionmightnotbelimitedtotheoligodendrocyticlineage.Olig2hasfurtherbeenshowntobecriticalintheproliferationofmalignantgliomainbraintumors(Ligonetal.,2007)
Liquidin100mMGlycine,200mMTris,pH8.0.Containsnopreservative.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforforuptooneyearafterdateofreceipt.Avoidfreeze/thawcycles.
Kucharova,K.,&Stallcup,W.B.(2015).NG2-proteoglycan-dependentcontributionsofoligodendrocyteprogenitorsandmyeloidcellstomyelindamageandrepair.Journalofneuroinflammation,12(1),161.PMID:26338007
Mauney,S.A.,Pietersen,C.Y.,Sonntag,K.C.,&Woo,T.U.W.(2015).Differentiationofoligodendrocyteprecursorsisimpairedintheprefrontalcortexinschizophrenia.SchizophreniaResearch,169(1),374-380.PMID:26585218
NorwoodJ,FranklinJM,SharmaD,D’MelloSR(2014)Histonedeacetylase3isnecessaryforproperbraindevelopment.JBiolChem.2014Dec12;289(50):34569-34582.PMID:25339172
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。