请使用支持JavaScript的浏览器!
主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/TrkB Antibody/2007-TrkB/100 µl
产品编号:2007-TrkB
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/TrkB Antibody/2007-TrkB/100 µl
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Rat
Applications:
WB1:1,000
Species:
Rabbit
MolecularReference:
~93kDa
CiteThisAntibody:
PhosphoSolutionsCat#2007-TRKB,RRID:AB_2492266
Antigen/Purification:ExpandCollapse

TheantigenisasyntheticpeptidecorrespondingtoaminoacidresiduesfromtheC-terminalregionofratTrkB.

TheantibodyispreparedfrompooledrabbitserumbyaffinitypurificationonacolumnmadewiththeC-terminalpeptideusedasantigen.

BIOLOGicalSignificance:ExpandCollapse

Tropomyosin-receptor-kinase(TRK)receptorsaremembersofthereceptortyrosinekinasefamilyandincludeTrkA,TrkBandTrkC.Eachofthesereceptortypeshasdifferentbindingaffinitiestotheneurotrophinsnervegrowthfactor(NGF),brain-derivedneurotrophicfactor(BDNF)andneurotrophin3(NT-3).TrkBhasthehighestaffinitytobindingBDNFwhichplayscriticalrolesinthefunctionandsurvivalofneuronsintheCNS(Soppetetal.,1991;Kleinetal.,1991).Additionally,alterationsinexpressionofTrkBhavebeenassociatedwithAlzheimer’sdisease(Ferreretal.,1999;Chenetal.,2008).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternblots.

Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.

GeneralReferences

SoppetD,EscandonE,MaragosJ,MiddlemasDS,ReidSW,BlairJ,BurtonLE,StantonBR,KaplanDR,HunterT,NikolicsK,ParadaLF(1991)Theneurotrophicfactorsbrain-derivedneurotrophicfactorandneurotrophin-3areligandsforthetrkBtyrosinekinasereceptor.Cell.May31;65(5):895-903.

KleinR,NanduriV,JingSA,LamballeF,TapleyP,BryantS,Cordon-CardoC,JonesKR,ReichardtLF,BarbacidM(1991)ThetrkBtyrosineproteinkinaseisareceptorforbrain-derivedneurotrophicfactorandneurotrophin-3.Cell.Jul26;66(2):395-403.

FerrerI,MarínC,ReyMJ,RibaltaT,GoutanE,BlancoR,TolosaE,MartíE(1999)BDNFandfull-lengthandtruncatedTrkBexpressioninAlzheimerdisease.Implicationsintherapeuticstrategies.JNeuropatholExpNeurol.Jul;58(7):729-39.

ChenZ,SimmonsMS,PerryRT,WienerHW,HarrellLE,GoRC.(2008)Geneticassociationofneurotrophictyrosinekinasereceptortype2(NTRK2)WithAlzheimer’sdisease.AmJMedGenetBNeuropsychiatrGenet.Apr5;147(3):363-9.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

自营商城图标
厂家直采
全球直采 正品优价
正品保障图标
正品保障
厂家直发 有线跟踪
解放采购图标
正规清关
CIF100%正规报关,提供发票
及时交付图标
及时交付
限时必达 不达必赔