PhosphoSolutions/Serotonin Transporter (Thr276) Antibody/p1700-276/100 µl,PhosphoSolutions,,PhosphoSolutions,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：PhosphoSolutions/Serotonin Transporter (Thr276) Antibody/p1700-276/100 µl

产品编号：p1700-276

市场价：¥4574.70

场地：美国(厂家直采)

产品分类：抗体类>一抗>功能性抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$345.00

品牌： PhosphoSolutions

公司：PhosphoSolutions

公司分类：

商品介绍

Rabbitpolyclonalantibody

PooledSerum

Size:: 100µl
Formulation:: AffinityPurifiedfromPooledSerum
Specificity:: Rat,Mouse,Human,Xenopus,Bovine,Non-humanprimate,Sheep
Applications:: WB1:1000
Species:: Rabbit
MolecularReference:: ~76kDa
CiteThisAntibody:: PhosphoSolutionsCat#p1700-276,RRID:AB_2492237

Antigen/Purification:ExpandCollapse

Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Thr²⁷⁶ofratSERT.

Theantibodyispreparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

TheSEROtonintransporter(SERT)recyclesserotoninbytransportingitbacktothepre-synapticcell.Itistheprimarytargetformostanti-depressantdrugsandforstimulantssuchasmethamphetamines.SERTisregulatedbyseveralprocesses,includingacyclicGMPsignalingpathwayinvolvingnitricoxidesynthase,guanylylcyclase,andcGMP-dependentproteinkinase(PKG).cGMP-andPKG-mediatedSERTregulationrequiresphosphorylationatthr²⁷⁶(Ramamoorthyetal.,2007).IthasbeensuggestedthatalthoughPKGisinvolvedinthestimulationofSERTatthr²⁷⁶,itdoesnotdirectlyphosphorylatetheresidue,ratheritinitiatesakinasecascadethatleadstoSERTphosphorylationbyanasyetunidentifiedproteinkinase(Wongetal.,2012).Alsooftherapeuticimportance,mutationatthethr²⁷⁶residuehasbeenshowntodecreasethepotencyofavarietyofanti-depressantdrugs,(ZhangYWandRudnickG,2005).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

ProductSpecificReferences

Zhang,Y.W.,Turk,B.E.,&Rudnick,G.(2016).Controlofserotonintransporterphosphorylationbyconformationalstate.ProceedingsoftheNationalAcademyofSciences,113(20),E2776-E2783.PMID:27140629

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik，他们在 Paul Greengard 博士的实验室共同工作，Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区，是一支敬业、友好、勤奋的科学家团队，致力于为您提供最优质的抗体和业内客户支持。

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