请使用支持JavaScript的浏览器!
主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/p62 (Ser28) Antibody/p196-28/100 µl
产品编号:p196-28
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/p62 (Ser28) Antibody/p196-28/100 µl
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Human,Non-humanprimate
Applications:
WB1:500
Species:
Rabbit
MolecularReference:
~48kDa
CiteThisAntibody:
PhosphoSolutionsCat#p196-28,RRID:AB_2492197
Antigen/Purification:ExpandCollapse

Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser28ofp62.

Theantibodyispreparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

p62,alsoknownassequestosome1(SQSTM1),isashuttleproteintransportingpolyubiquitinatedproteinsforbothproteasomalandlysosomaldegradation.p62isanintegralcomponentofinclusionsinbrainsofvariousneurodegenerativedisorders,includingAlzheimerdisease(AD)neurofibrillarytangles(NFTs)andLewybodiesinParkinsondisease(Nogalaskaetal.,2009).p62playsanimportantroleintheprotectionofcellsfromthetoxicityofmisfoldedproteinsbyenhancingaggregateformationespeciallyinthelaterstages(Nakasoetal.,2004).PhosphorylationofSer28hasrecentlybeendemonstratedtoberelatedtothepathogenesisofParkinson’sdisease.

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgBSApermland50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

NogalskaA,TerraccianoC,D’AgostinoC,EngelWK,AskanasV(2009).p62/SQSTM1isoverexpressedandprominentlyaccumulatedininclusionsofsporADIcinclusion-bodymyositismusclefibers,andcanhelpdifferentiatingitfrompolymyositisanddermatomyositis.ActaNeuropathol.3:407-13.

NakasoK,YoshimotoY,NakanoT,TakeshimaT,FukuharaY,YasuiK,AragaS,YanagawaT,IshiiT,NakashimaK.(2004).Transcriptionalactivationofp62/A170/ZIPduringtheformationoftheaggregates:possIBLemechanismsandtheroleinLewybodyformationinParkinson’sdisease.BrainRes.1-2:42-51.

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

自营商城图标
厂家直采
全球直采 正品优价
正品保障图标
正品保障
厂家直发 有线跟踪
解放采购图标
正规清关
CIF100%正规报关,提供发票
及时交付图标
及时交付
限时必达 不达必赔