请使用支持JavaScript的浏览器!
主营:神经科学领域的蛋白及抗体
℡ 4000-520-616
℡ 4000-520-616
PhosphoSolutions/p62 (Thr269 Ser272) Antibody/p196-269/100 µl
产品编号:p196-269
市  场 价:¥4574.70
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: PhosphoSolutions
公      司:PhosphoSolutions
公司分类:
PhosphoSolutions/p62 (Thr269 Ser272) Antibody/p196-269/100 µl
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Human,Non-humanprimate
Applications:
WB1:1,000
Species:
Rabbit
MolecularReference:
~62kDa
CiteThisAntibody:
PhosphoSolutionsCat#p196-269,RRID:AB_2492198
Antigen/Purification:ExpandCollapse

Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Thr269/Ser272ofhumanp62.

Theantibodyispreparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

Theproteinscaffoldandsignalingregulatorp62(alsoknownassequestosome1(SQSTM1))isimportantincriticalcellularfunctions,includingbonehomeostasis,obesity,andcancer,becauseofitsinteractionswithvarioussignalingintermediaries.p62isoverexpressedinmanyhumancancersandisinducedduringcelltransformation.cdk1phosphorylatesp62invitroandinvivoatThr<sup>269</sup>andSer<sup>272</sup>,whichisnecessaryforthemaintenanceofappropriatecyclinB1levelsandthelevelsofcdk1activitynecessarytoallowcellstoproperlyenterandexitmitosis(Moscatetal.,2011).Thelackofcdk1-mediatedphosphorylationofp62leadstoafasterexitfrommitosis,translatingintoenhancedcellproliferationandtumOrigenesisinresponsetoRas-inducedtransformation(Moscatetal.,2011).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgBSApermland50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

MoscatJ,LinaresJF,AmanchyR,Diaz-MecoMT(2011)Phosphorylationofp62bycdk1ControlstheTimelyTransitofCellsthroughMitosisandTumorCellProliferation.MolCellBiol.1:105-17.

PankivS,LamarkT,BruunJA,ØvervatnA,BjørkøyG,andJohansen(2010).NucleocytoplasmicShuttlingofp62/SQSTM1andItsRoleinRecruitmentofNuclearPolyubiquitinatedProteinstoPromyelocyticLeukemiaBodies.JBiolChem.8:5941-53

品牌介绍

PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。

自营商城图标
厂家直采
全球直采 正品优价
正品保障图标
正品保障
厂家直发 有线跟踪
解放采购图标
正规清关
CIF100%正规报关,提供发票
及时交付图标
及时交付
限时必达 不达必赔