Rabbitpolyclonalantibody
TheantigenisanativePEBPproteinpurifiedfromrat.
Theantibodyisneatserum.
Phosphatidylethanolaminebindingprotein(PEBP),alsoknownasRafkinaseinhibitoryprotein(RKIP)isahighlyconservedmultifunctionalproteinthatmodulatestheRaf/MAPKsignalingcascadeandhasbeenimplicatedasasuppressorofmetastaticcancer(TrakulNetal.,2005).PEBPhasbeenshowntonotonlyinhibitcellproliferationbutalsotoinducedifferentiationofhumankeratinocytes(Yamazakietal.,2004).DysregulationofcalpainactivityresultsincellulardegenerationinconditionssuchasAlzheimer’sdiseaseandrecentlyPEBPhasbeenidentifiedasapotentialinvivocalpainsubstrate(Chenatal.,2006).
100ulneatserum.
Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.
TrakulN,MenardRE,SchadeGR,QianZ,RosnerMR(2005)RafkinaseinhibitoryproteinregulatesRaf-1butnotB-Rafkinaseactivation.J.Biol.Chem.280(26):24931-40.
YamazakiT,NakanoH,HayakariM,TanakaM,MayamaJ,TsuchidaS(2004)Differentiationinductionofhumankeratinocytesbyphosphatidylethanolaminebindingprotein.J.Biol.Chem.279(31):32191-95.
ChenQ,WangS,ThompsonSN,HallED,GuttmannRP(2006)IdentificationandcharacterizationofPEBPasacalpainsubstrate.JNeuRochem.99(4):1133-41.
PhosphoSolutions 由 Drs 于 2001 年创立。Michael D. Browning、John W. Haycock 和 Andrew J. Czernik,他们在 Paul Greengard 博士的实验室共同工作,Paul Greengard 博士因研究蛋白质磷酸化在信号转导中的作用而共同获得 2000 年诺贝尔医学奖在神经系统中。这种专业知识使我们主要关注神经科学领域中感兴趣的蛋白质。我们位于科罗拉多州奥罗拉的 Fitzsimons 生命科学园区,是一支敬业、友好、勤奋的科学家团队,致力于为您提供最优质的抗体和业内客户支持。